Clinical observation of dexmedetomidine combined with ketamine in pediatric ophthalmic surgery
ZHU Cheng-yun
Abstract：Objective To observe the safety and anesthetic effect of dexmedetomidine combined with ket -amine in pediatric ophthalmic surgery .Methods Ninety children aged 2~7 years received ophthalmic surgery were randomly divided into 3 groups(30 cases in each group):group A:ketamine combined with dexmedetomidine;group B:ketamine and midazolam;group C:ketamine.The tested indexes were recorded before anesthesia (T0), at 5 min after intramuscular injection of ketamine(T1), at operation beginning(T2), at 5 min after operation beginning(T3), at 15 min after operation beginning(T4) and at the end of operation(T5) of SBP, DBP, HR, SpO2.The total dosage and the occurrence of adverse reactions of with ketamine were recorded .The postoperative recovery time and agitation occurrence were observed .Results Between group A and group C , there were significant differences in SBP at T 1, T3, T5 and in DBP at T5(P<0.05).Between group A and group B, group C there was statistically significant differences in HR at T5(P<0.05).The total dosage of ketamine and the number of cases of adverse reactions in group A and group B were different from those in group C ( P<0.05 ) .The recovery time in group A and group B were less than those in group C with a significant difference between group A and group C ( P<0.05 ) .The incidence of agitation in group A was lower than those group B and group C ( P<0.05 ) .Conclusion Anesthesia of dexmedeto-midine combined with ketamine for pediatric ophthalmic surgery is safe , and has the advantages of stable hemodynam-ic state, less adverse reactions , lower incidence of postoperative agitation .
Keywords：DexmedetomidineKetamineChildrenOphthalmology surgery
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 39-42 )