Platelet-leukocyte aggregates in patients with surgery under general anesthesia
WANG Sheng
LI Xin-gang
ZHAO Ji-quan
Abstract：Objective To monitor the platelet-leukocyte aggregates ( PLA) level in patients received surgery under general anesthesia and to explore the potential mechanism of deep vein thrombosis occurred in these patients . Methods Blood samples were collected from 112 patients received surgery at the time:before the general anesthesia;immediately after the surgery , and 3 days after the surgery .Flow cytometry was used to measure the platelet-neutro-phil aggregates ( PNA ) and platelet-monocyte aggregates ( PMA ) .Results Before the general anesthesia: PNA (19.32 ±3.48)%, PMA(26.86 ±5.05)%;Immediately after the surgery:PNA(19.48 ±3.20)%, PMA(31.86 ± 5.31)%;Three days after the surgery:PNA(21.85 ±2.84)%, PMA(77.69 ±5.72)%; Statistical analysis: the PNA and PMA level in patients immediately after the surgery and that in patients three days after surgery were higher than that patients before the general anesthesia ( P<0.01 ) .Conclusion The PNA and PMA level , especially , the PMA level in patients received surgery is affected by general anesthesia .PNA and PMA can be used as a sensitive bi-omarker to determine the degree of platelet activation and to predict the possible postoperative thrombosis .
Keywords：Platelet-leukocyte aggregates ( PLA)Surgery under general anesthesiaFlow cytometry
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 33-36 )