The change of plasma pro B-type natriuretic peptide level and its clinical significance in patients with liver cirrhosis
Abstract：Objective To investigate the value of plasma pro B-type natriuretic peptide level in diagnosis of cirrhotic cardiomyopathy(CCM).Methods Plasma proBNP levels,the changes on ECG(QTc,QTd,QTcd and Pd) were measured and evaluated in 38 patients with cirrhosis and 20 healthy controls , and compared between the two groups.In patients with cirrhosis , the association between the changes on ECG and CTP score ,MELD score,proBNP levels were analyzed .Results ProBNP was significantly higher in patients with cirrhosis ( 228.0 ±83.4 ) fmol/ml than in healthy controls(127.4 ±21.1 )fmol/ml.And in patients with cirrhosis,the changes on ECG, QTc、QTd, QTcd and Pd, were (446.9 ±28.0)ms1/2,(36.4 ±6.6)ms,(40.6 ±9.0)ms1/2,(22.8 ±4.8)ms respectively and significantly increased compared with healthy subjects (417.2 ±21.5)ms1/2,(29.6 ±4.9)ms,(31.1 ±4.9)ms1/2, (19.0 ±4.1)ms, and positively related to CTP score,MELD score and proBNP level.Conclusion The plasma level of proBNP was valuable for diagnosis of CCM ,and correlated with the severity of CCM .
Keywords：Liver cirrhosis ( LC )Cirrhotic cardiomyopathy ( CCM )Pro B-type natriuretic peptide (proBNP)Electrocardiogram(ECG)
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1163-1166 )