Retroperitoneal dedifferentiated liposarcoma with heterogeneous differentiation:a case report and review of literature
Abstract：Objective To explore the character of molecular genetics ,clinicopathologic features,diagnosis and differential diagnosis of retroperitoneal dedifferentiated liposarcoma with heterogeneous rhabdomyosarcoma and neuroendocrine differentiation .Methods A retrospective analysis was performed on clinicopathologic process , immu-nohistochemistry , histopathology diagnosis and differential diagnosis in a case of dedifferentiated liposarcoma with het -erogeneous rhabdomyosarcoma and neuroendocrine differentiation and related literature were reviewed .Results There were two elements in the tumor .The differentiated elements included well-differentiated Lipoma-like liposarcoma and inflammation-xanthogranuloma;dedifferentiated element included high-grade malignant pleomorphism undifferentiated sarcoma and low-grade malignant aggressive fibromatosis and myxofibrosarcoma .The dedifferentiation components in-cluded heterogeneous rhabdomyosarcoma and neuroendocrine differentiation .Immunohistochemistry assay showed posi-tive included: Viment,CD68,CDK4,FLi-1,MyOD1,Myogenin,NSE,CD56,Bcl-2,Desim,negative included CD34, LCA,MDM2,CK-AE1/AE3.Suspectde positive included CgA ,Syn,S-100,CD99.Ki-67( +) >60%.Conclusion The retroperitoneal enormous tumor has two distinct differentiations and morphologic components with heterogeneous components differentiations .The complexity and polymorphism often make diacrisis difficult .It is important to master histopathology and immunohistochemistry in diagnosis and differential diagnosis of this tumor .
Keywords：DedifferentiatedLiposarcomaHistopathologyImmunohistochemistry
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1065-1068 )