Correlation study of target organ damage in diabetes patients

doi:10.3969/j.issn.1674-3806.2013.11.11

Abstract：Objective To explore the main influence factors of the target organ damage in the diabetes pa-tients.Methods Fifty-six diabetes patients with target organ damage ( ODM group) and 40 diabetes patients without with target organ damage (DM group) were detected.The urine micro protein was tested with automatic chemical im-mune luminescence method and the albumin excretion rate ( UAER) was calculated .D-D was detected with fully auto-matic blood coagulation analyzer and serum hs-CRP levels with scattering turbidimetric method .Color doppler ultra-sound was used for detecting common carotid artery intima-media thickness ( IMT) and left ventricular mass index (LVMI).The detected abnormal results were used as indexes of target organ damage in the diabetes patients and the two groups were compared of gender , age, course, glycosylated hemoglobin(HbA1c), total cholesterol(TC), triglyc-erides(TG), low density lipoprotein cholesterol (LDL-C), hypertension.Results Course,age, HbA1c,TC,TG, LDL-C, hypertension , UAER, hs -CRP, D-D were increased in ODM group , compared with DM group ,the differ-ence between two group were statistically significant ( P<0.01 ) .The multi-factor Logistic stepwise regression analysis showed that LDL-C、hs-CRP had significant effect on the target organ damage in diabetes patients ( P<0.05 ) .Con-clusion LDL-C,hs-CRP are closely related to the occurrence and development of target organ damage in diabetes pa -tients, and can be used as reference indexes for evaluating prognosis and therapeutic effect of diabetes .