Clinical analysis of 16 cases of reversible posterior leukoencephalopathy syndrome
Abstract：Objective To analyze the etiology and clinical features of reversible posterior leukoencephalopa -thy syndrome , and search for the ways of early diagnosis and treatment .Methods A retrospective analysis was per-formed in 16 patients with reversible posterior leukoencephalopathy syndrome treated in our hospital from February 2010 to February 2013 including the etiology , clinical characteristics , treatment and prognosis .Results There were 16 patients including 6 males and 10 females.There were 7 cases with hypertensive encephalopathy including 4 cases with renal insufficiency;4 cases with eclampsia;2 cases with multiple aortitis;1 case with thrombotic thrombocytopenic purpura;1 case with systemic lupus erythematosus and 1 case with right internal carotid artery endarterectomy .The clinical manifestations mainly included headache , delirium, consciousness disorders , seizure disorder and visual hal-lucinations .Brain MRI examination showed the lesions for T 1-weighted short signal and T 2-weighted elongated signal in the white matter of the posterior cerebral hemispheres and invariably bilateral symmetry .After appropriate dehydra-tion, depressing the intracranial pressure ,and improving circulation and hyperbaric oxygen therapy in time ,in all the 16 patients,the symptoms and signs disappeared in 14 patients(accounted for 87.5%),significantly improved in 2 patients(12.5%).Conclusion The disease is a clinical syndrome with etiology and clinical characteristics .There is better prognosis for most of them by timely and effective treatment .
Keywords：Reversible posterior leukoencephalopathy syndrome ( RPLS)EtiologyClinical analysis
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 977-979 )