Comparison of clinical curative effects between mosapride and domperidone in treating postprandial discom- fort syndrome
CHEN Zhi-jun
HUANG Zi-cheng
LIN Jin-gui
Abstract：Objective To compare the therapeutic effects between mosapride and domperidone in the treat -ment of postprandial discomfort syndrome ( PDS) .Methods Fifty-eight cases of PDS according to RomeⅢPDS diag-nostic criteria were randomly assigned into two groups according to admission order .In the A group ,30 cases patients were treated with mosapride tablets:5 mg 3 times daily, taken before meals, in the B group, 28 patients were treated with domperidone tablets:10 mg, 3 times daily, taken before meals, the course were 28 days.After the end of treat-ment,the efficacy and adverse drug reaction were compared between two groups .Results The total effective rate in the A group was 93.3%and the total effective rate in the B group was 67.9%.There was a statistically significant difference in total effective rate between two groups ( P <0.05 ) .There was minor adverse drug reactions in two groups.Conclusion The therapeutic effects of mosapride and domperidone in treating PDS are good with minor ad -verse reactions .But mosapride is superior to domperidone in the total effective rate .
Keywords：Postprandial discomfort syndromeMosaprideDomperidoneClinical observation
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 968-970,971 )