Performance evaluation of EB virus Rta-IgG quantitative detection kit and its application in diagnosing naso- pharyngeal carcinoma
Abstract：Objective To investigate the clinical value of Epstein-Barr virus ( EBV) Rta/IgG in the diagno-sis of nasopharyngeal carcinoma ( NPC) .Methods Sera from 612 clinical samples were measured for the Rta-IgG by an indirect enzyme-linked immunosorbent assay .In the present study , we also evaluated the performance of the Rta-IgG ELISA kits.Results The mean value of Rta-IgG concentration in 267 NPC patients was (77.64 ±3.205)U/ml with a sensitivity of 94.7%( 214/226 ) and specificity of 86.3%( 333/386 ) and accuracy of 89.4%( 547/612 ) . The mean value of Rta-IgG concentration in 255 healthy volunteers ,20 hepatocellular carcinoma patients ,30 hepatitis patients,20 patients with autoimmune disease and 20 patients with nasopharyngeal polyp were (8.31 ±0.745)U/ml, (7.14 ±1.111)U/ml, (7.40 ±0.581)U/ml, (13.97 ±6.943)U/ml and (12.58 ±6.197)U/ml, respectively. There were significant difference between NPC group and other groups .Conclusion Our results suggest that the EBV Rta/IgG ELISA kit is suitable for the clinical diagnosis of NPC .It also provides a basis for further study on the rela-tionship between the therapeutic effect and serum EBV Rta-IgG content in NPC patients .
Keywords：EBV Rta-IgGQuantitative detectionNasopharyngeal carcinoma ( NPC)Diagnosis
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 942-944 )