Clinical effect of lowm-olecular-weight heparin calcium on severe neph rotic syndrome
Abstract：Objetc ive To investigate the effects of low -molecular-weight heparin calcium ( LMWH) in pa-tients with primary severe nephritic syndrome ( PSNS) .Methods Forty patients with PSNS were divided randomly in-to treated groups(n=21) which was treated with LMWH of 5 000 U· d-1 injection under skin and control group (n=19) which was treated with Dipyridamole50 mg three times every day for 4 weeks.Two groups were treated with the same base of steroid and Fenofibrate .Plasma FIB, 24 h urinary protein, Scr, ALB, TCHO, TG, PLT, PT and APTT were observed.Results A significant decrease of plasma FIB , serum TCHO and TG was observed in the treated group compared with those in the control group after 4 weeks of treatment ( P<0.05 ) .A significant decrease of 24 h urinary protein and increase of serum ALB was observed in the treated group compared with those in the control group after 4 weeks of treatment ( P<0.05 ) .Only 2of the 21 patients in treated group complained of ecchymosis under skin.Conclusion The treatment with LMWH for PSNS can significantly decrease plasma FIB and protect against high thrombotic risk of PSNS, LMWH for PSNS can significantly decrease 24 h urinary protein, serum TCHO, TG and increase serum ALB , and it is helpful to relieve PSNS .
Keywords：Primary nephritic syndromeLow-molecular-weight heparin calciumHypercoagulation stateUrinary Protein
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 929-931,932 )