Correlation study of nonalcoholic fatty liver disease and primary hepatocellular carcinoma

TIAN Jing-hui; TANG Yan-xia

doi:10.3969/j.issn.1674-3806.2013.08.14

Abstract： Objective To investigate the incidence , clinical characteristics , risk factors of nonalcoholic fatty liver disease(NAFLD) with primary hepatocellular carcinoma (HCC).Methods A retrospective analysis was per-formed.From 1 092 hospitalized patients with HCC , according to “clinical diagnostic criteria for nonalcoholic fatty liv-er disease in nonalcoholic fatty liver disease diagnosis and treatment guidelines ” of fatty liver and alcoholic liver dis-ease study group of Chinese Liver disease Association ,72 HCC patients were selected who met the diagnostic criteria of NAFLD.In 72 patients with NAFLD with HCC, incidence, clinical and biochemical indexes , imaging characteris-tics, survival rate and the risk factors influencing the prognosis were analyzed .Results In 1 092 HCC patients, there were 72 patients with NAFLD, accounted for 6.6%, average age (60.52 ±10.21 );with type 2 diabetes melli-tus in 35 cases,accounted for 48.6%(35/72);body mass index ≥26 kg/m2 in 28 cases, accounted for 38.9%(28/72);hypertension 34 cases, accounted for 47.2%(34/72).The main clinical manifestations had no obvious charac-teristic.In follow-up of 72 patients with NAFLD with primary HCC, 53 cases died;1, 2, 3 year survival rates were 68.47%, 40.26%, 30.52%.BMI, T2DM, hypertension, ALT, TBIL, DBIL, GGT, CHE on survival rate of NAFLD patients with HCC were statistically significant in univariate analysis , may be the risk factors influencing the prognosis.Multivariate analysis showed that BMI , T2DM were independent prognostic factors .Conclusion NAFLD is the primary reason for the occurrence of HCC .Obesity, T2DM are independent risk factors influencing the prognosis of patients with NAFLD with HCC .