XRCC1 Arg194Trp, Arg280His, Arg399Gln polymorphisms and prostate cancer risk:a Meta-analysis
Abstract： Objective To evaluation the relationship between X-ray repair cross-complementing group 1 (XRCC1) single nucleotide polymorphisms (SNPs) and genetic susceptibility to prostate cancer (Pca) risk.Meth-ods We searched on MEDLINE , EMBASE and OVID , collected and abstracted the case-control studies about XRCC1 codon 194 , 280 , 399 polymorphisms and genetic susceptibility of Pca;did Meta-analysis by Stata , Odds rati-os (ORs) and 95%confidence interval (95%CI) were calculated to evaluate correlation strength; the relation be-tween smoking and Pca was analyzed by SPSS , O<R evaluated relative risk of smoking .Results XRCC1 399 Gln/Gln and XRCC1 280 Arg/His were related with risk for Pca ( Gln/Gln vs Arg/Arg:O<R=1.27 , 95%CI=1.02~1.59;Arg/His vs Arg/Arg:O<R=1.66 , 95%CI=1.09~2.52 ) , especially Asian Gln/Gln obviously increased risk for Pca ( O<R =1.52 , 95%CI=1.18~1.96 );Arg194 Trp was not related with risk for Pca .Smoking was a risk factor of Pca (χ2 =13.974 , P=0.000 , O<R=1.22 ) .Conclusion XRCC1 399 Gln/Gln and XRCC1 280 Arg/His were probably related with genetic susceptibility to Pca .
Keywords：Prostate cancerX-ray repair cross-complementing group 1Genetic polymorphismsMe-ta-analysis
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 757-762 )