Effect of metformin on proliferation and apoptosis of human endometrial carcinona cells
SONG Hong-lin
LI-ANG Shao-feng
Abstract： Objective To investigate the effect of metformin on proliferation , cell cycle distribution and ap-optosis of human endometrial carcinoma cell lines in vitro .Methods The effects of metformin on proliferation , cell cycle distribution and apoptosis of Ishikawa cell lines were measured by MTT assay and fluorescence -activated cell sorting technique .Results Metformin potently inhibited growth in a dose-dependent manner in Ishikawa cell lines in a dose-and time-dependent fashion .Flow cytometric analysis showed that metformin increased the number of cells in G0/G1 and reduced the percentage of cells in S phase .Conclusion Metformin is a potent inhibitor of cell prolifera-tion in endometrial cancer cell lines .
Keywords：Endometrial carcinomaMetforminCell proliferationCell apoptosis
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 739-741 )