Effects of the change of GLP-1 level on glucagon and early phase insulin secretion in the patients with the newly diagnosed type 2 diabetes
Abstract： Objective To explore the effects of the change of Glucagon-like peptide-1 level on glucagon and early phase insulin secretion in the patients with the newly diagnosed type 2 diabetes.Methods Patients with the newly diagnosed type 2 diabetes(T2DM group) and healthy volunteers(control group) were used as the research ob-ject, and the standardized bread meal test was used to observe effects of the dynamic changes of GLP -1 level at 0 min, 30 min and 120 min on plasma glucose , glucagon and insulin secretion .Results The levels of GLP-1 at each time point in newly diagnosed T2DM group were significantly reduced compared with those of the control group respec -tively(P<0.05);The levels of insulin at 30 min and 120 min were both significantly reduced compared with those of the control group respectively ( P <0.05 ) , but the difference had no statistical significance at 0 min between two groups(P>0.05);The levels of glucagon at each time point in newly diagnosed T 2DM group were significantly higher than that of the control group (P<0.05).The first-phase insulin secretion index of newly diagnosed T 2DM group was significantly reduced compared with those of the control group ( P<0.05 ) .Conclusion The levels of GLP-1 at each time point in newly diagnosed patients with type 2 diabetes mellitus were significantly reduced;GLP-1 dificiency might be the important factors of lack of islet beta cell secretion and insrease of glucagon secretion .
Keywords：Type 2 diabetes mellitusGlucagon-like peptide-1(GLP-1)GlucagonInsulin secretion index
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 736-739 )