Value of combined detection of Toll-like receptor 2 and interferon-γin the diagnosis of tuberculous pleural ef-fusion
Abstract： Objective To explore the value of the combined detection of Toll-like receptor-2(TLR2) and in-terferon-γ( IFN-γ) in pleural effusion in the diagnosis of tuberculous pleural effusion .Methods The concentrations of soluble TLR2 and IFN-γin pleural effusion and serum were determined by enzyme linked immunosorbent assay (ELISA) in patients with tuberculous, malignant and bacterial pleural effusion.Results (1)The concentrations of sTLR2[22.19 ±2.12)ng/L] and IFN-γ[(2 287.20 ±408.34)ng/L] in pleural effusions were significantly higher than those in serum of the same patients .The levels of sTLR2 and IFN-γin tuberculous pleural effusion was signifi-cantly higher than those in malignant and in bacterial pleural effusion .(2) The ROC analysis for TLR2 and IFN-γwere done.The levels of TLR2 generated an area under the receive operating characteristic (ROC) curve of 0.696 [95%confidence interval (CI):0.501~0.849], at a sensitivity of 66.67%, a specificity of 80%.As well as IFN-γgenerated an area under the ROC curve of 0.945(95%CI:0.875~1.014), at a sensitivity of 87.5%, a specificity of 97.9 %.Conclusion The combined decection of TLR 2 and IFN-γin pleural effusion may be helpful in the differ-ential diagnosis of tuberculous pleural effusion and the other pleural effusion , which provides an important information for clinical diagnosis and treatment .
Keywords：Tuberculous pleural effusionToll-like receptor-2Interferon-γ
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 733-736 )