The survey of three-year follow-up and the related risk factors of impaired fasting glucose and impaired glucose tolerance

doi:10.3969/j.issn.1674-3806.2009.07.17

Abstract：Objective To investigate the natural outcome and the related risk factors in subjects with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). Methods During April 2006 to June 2006, 79 subjects with IFG and IGT, who had been diagnosed as abnormal glucose metabolism based on a diabetes mellitus census of 1 062 citizens in Chaoyang city from April 2003 to June 2003, were examined with height, weight, waist circumference,blood pressure, and 75 g oral glucose tolerance test (OGTT). Meanwhile, serum total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) were also tested.Results Of the 65 subjects 22 subjects had diabetes mellitus(DM). Among them the conversion rates to DM were 10.8 %, 9.2 %, and 10.4% for the subjects with I-IFG, I-IGT, and IFG/ IGT, respectively. With the age increasing, abnormal glucose metabolism, hypertension, obesity and abnormal lipid metabolism became much severer. Incidence of abnormal glucose metabolism obviously increased in the subjects aged above 40 years. The results of mono-factor analysis showed that glucose increase may be related to the aging, DM family history, work intensity, increase of waist circumference and systolic blood pressure, abnormal blood fat. Logistic regression found that aging, central obesity, hypertension and less physical work were all the risk factors of DM. Conclusion Cumulative life-incidence of DM in the subjects with I-IGT, IGT/IFG is significantly higher than that in the subjects with I-IFG. Aging, central obesity, hypertension and less physical work are the main risk factors of abnormal glucose metabolism. Therefore, it is essential to control blood pressure and body weight and enhance physical exercise in order to prevent from DM.