Bone marrow morphocytology in 34 systemic lupus erythematosus patients with peripheral cytopenia
Abstract：Objective To 1earn bone marrow morphocytology in systemic lupus erythematosus(SLE) patients with peripheral cytopenia.Methods The smears of bone marrow aspirates obtained from 34 SLE patients who had bone marrow aspiration due to peripheral cytopenia (WBC<4×109/L, or Hb<100 g/L, or platelet count<100×109/L) were examined retrospectively.And the smears of the bone marrow aspirates obtained from 14 healthy controls,18 patients with MDS (refractory anemia), and 26 patients with idiopathic thrombocytopenic purpura (ITP) were inserted randomly among those obtained from the SLE patients.Results Of the 34 SLE patients, 24(70.6%) had dysplasias, including: erythroid cell multinuclearity (trinuclear or more) 10(29.4%), megaloblastoid changes 8(23.5%), pseudo Pelger-Hüet abnormalities 12(35.3%),separated nuclear megakaryocytes 8(23.5%), and micromegakaryocytes 10(29.4%).Conclusion This study found that bone marrow dysplasia can be observed in all lineage cells of SLE patients, We conclude that the bone marrow may be a target organ in SLE with cytopenia.
Keywords：Systemic lupus erythematosusBone marrowCytopeniaDysplasias
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 691-693 )