Expression and significance of IGF-I and IGF-IR in different part of keloid
Abstract：Objective To explore the aggressive growth characteristics in peripheral parts and central parts of keloid by analysing the insulin-like growth factor-I (IGF-I) and the insulin-like growth factor-I receptor (IGF-IR) index.Methods Fibroblasts of 8 keloids cases and 4 normal skin cases were investigated by immunohistochemical analysis of IGF-I and IGF-IR. IGF-I and IGF-IR index of difference parts in keloids and normal skin were compared.Results These were no positive fibroblasts in normal skin samples. The IGF-I and IGF-IR index of peripheral parts of keloids are higher than those of central parts, and there is significant difference(P<0.05).Conclusion The difference in distribution of IGF-I and IGF-IR index may be responsible for the aggressive growth of keloid.
Keywords：KeloidIGF-IIGF-IRFibroblast
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 688-690 )