Influencing factors for peripheral neuropathy in type 2 diabetes patients:a meta-analysis
LIU Ke
LEI Jing
NIU Wenchang
PING Yanru
JIA Zhumin
Abstract：Objective To analyze the influencing factors of peripheral neuropathy among type 2 diabetic patients.Methods Studies on influencing factors of peripheral neuropathy among type 2 diabetic patients were searched in PubMed,the Cochrane Library,Embase,Web of Science,CBM,CNKI,WanFang and VIP databases,with the time setting from inception to 1st January 2023.Two reviewers screened the literature independently,extracted information and assessed the risk of bias of the included studies.Results A total of 25 studies were included.Meta analysis results showed that the main influencing factors of peripheral neuropathy in type 2 diabetes patients included age[MD=5.45,95％CI(3.96,6.94),P＜0.001],course of disease[MD=3.55,95％CI(1.84,5.26),P＜0.001],HbA1c[MD=1.20,95％CI(0.85,1.55),P＜0.001],fasting blood glucose[MD=1.93,95％CI(1.09,2.77),P＜0.001],2 h postprandial blood glucose[MD=3.24,95％CI(2.27,4.20),P＜0.001],systolic blood pressure[MD=5.81,95％CI(4.23,7.40),P＜0.001],serum creatinine[MD=16.47,95％CI(15.66,17.29),P＜0.001],insulin use[OR=2.54,95％CI(1.83,3.54),P＜0.001],diabetic retinopathy[OR=3.25,95％CI(2.69,3.93),P＜0.001],diabetic nephropathy[OR=2.81,95％CI(2.18,3.62),P＜0.001]and pulse wave velocity(PWV)[MD=1.32,95％CI(0.95,1.70),P＜0.001].Conclusion There are many factors affecting peripheral neuropathy in patients with type 2 diabetes,and medical staff should take predictive intervention measures according to individual conditions of patients to reduce the risk of diabetic peripheral neuropathy.
Keywords：Type 2 diabetesPeripheral neuropathyInfluence factorsMeta-analysis
Publication Date：2024-07-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 433-438 )