Comparative analysis of aminophylline and pentoverine in the treatment of senile sleep apnea syndrome

Gao Yanli; Dong Feifei; Yin Xuefang

doi:10.19617/j.issn1001-1307.2024.06.157

Abstract：Objective To systematically analyze the effects of aminophylline and pentoverine in the treatment of senile sleep apnea syndrome.Method Seventy-four elderly patients with sleep apnea treated in our hospital from April 2020 to April 2022 were selected as research objects,and were equally divided into control group and observation group based on"different treatment methods".37 patients were included in each group.The control group was treated with aminophylline,while the observation group was treated with aminophylline combined with pentoverine.Effects,sleep apnea hypopnea index,duration of sleep disordered breathing,nocturnal oxygen saturation,and incidence of drug side effects were systematically analyzed in both groups.Results Before treatment,there was no statistical difference between the sleep apnea hypopnea index and overnight blood oxygen saturation between the two groups,P＞0.05.After treatment,compared with the control group,the sleep apnea hypopnea index and blood oxygen saturation in the observation group were significantly better,P＜0.05;After treatment,the maintenance time of sleep disordered breathing in observation group was significantly shorter than that in control group,P＜0.05;After treatment,compared with the control group,the effect of observation group was significantly higher,P＜0.05;After treatment,the incidence of drug side effects was slightly higher in the observation group compared with the control group,but there was no statistical difference in data comparison P＞0.05.Conclusions The combination of aminophylline and pentoverine in elderly patients with sleep apnea can actively improve the effect,effectively improve the hypopnea index and nighttime blood oxygen saturation,shorten the maintenance time of sleep apnea disorders,improve drug safety,and provide a new idea for clinical treatment.