Efficacy and safety of esomeprazole combined with itopride in the treatment of acid reflux disease laryngitis
Wang Lele
Wang Guixia
Abstract：Objective To explore the efficacy and safety of esomeprazole combined with itopride in the diagnosis and treatment of acid reflux disease pharyngitis.Methods A total of 78 patients with acid reflux disease pharyngolaryngitis from January 2022 to January 2022 were randomly 2023,the patients were divided into control group(treated with esomeprazole)and treatment group(treated with esomeprazole and itopride)in equal proportion.The efficacy,symptom score and safety of the two groups were compared.Results 1 the effective rate of treatment:the effective rate of treatment group was 97.44%,which was higher than that of control group(p<0.05),2 the effect of symptom management:Based on the Index of reflux symptom and physical sign,the effective rate of treatment group was lower than that of control group(p<0.05);3 safety:in the incidence of diarrhea and headache(P>0.05),4 laboratory indexes:after treatment,the levels of ET-1 and NO in the treatment group were lower than those in the control group,and the levels of GAS and MTL were higher than those in the control group(p<0.05).Conclusion combined with itopride is effective in the diagnosis and treatment of acid reflux disease pharyngolaryngitis.It is helpful to relieve symptoms,improve gastric motility and is safe.
Keywords：Acid reflux disease laryngitisEsomeprazoleItoprideSafetyGastric motilityEfficacy
Publication Date：2024-07-27
Online Publishing Date：2025-11-27(First online date of this platform, not the publication date of the document)
Pages：3( 10-12 )