Advances in genes related to thyroid carcinoma

Abstract：The incidence of thyroid carcinoma increases worldwide with the development of diagnosis and has become one of the most commonly occurring endocrine system tumors. Usually,thyroid carcinoma can be classified into papillary thyroid carci-noma,follicular thyroid carcinoma,medullary thyroid carcinoma,poorly differentiated thyroid carcinoma and anaplastic thyroid carcinoma based on the histology and it has been reported that the prognosis closely connects with the histopathology of this tumor. Several genes such as IG20/MADD,RET and BRAF and molecules are involved in tumorigenesis in thyroid and studies at the mo-lecular level provide a promising approach for diagnosis and clinical therapy. Novel molecular-targeted therapy based on the molecu-lar pathophysiology has been in the stage of clinical trials and it brings hopes for refractory thyroid carcinomas.