Assessment of anesthetic quality of esmolol in elderly patients undergoing radical resection of colorectal cancer
SUN Yuwen
WANG Jian
WANG Haiqin
Abstract：Objective To explore the anesthesia quality of esmolol in elderly patients undergoing radical resection of colorectal cancer.Methods A prospective controlled study design was adopted.A total of 120 elderly patients undergoing radical resection of colorectal cancer admitted to Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from May 2021 to May 2024 were selected and divided into the control group(n=60)and the esmolol group(n=60)according to the random number table method.Both the esmolol group and the control group received tracheal intubation general anesthesia.The esmolol group was intravenously injected with 0.25-0.50 mg/kg esmolol before intubation,and maintained intravenously pumped with 50 μg/(kg·min)during surgery until 5 min before the end of surgery,and the control group was given the same amount of normal saline.The perioperative anesthesia indicators(anesthesia duration,time to awakening after entering the operating room,propofol dosage),hemodynamics parameters(mean arterial pressure(MAP),heart rate(HR),rate pressure product(RPP))and cardiovascular stress indicators(endothelin(ET),thromboxane B2(TXB2))before induction(T0),post-intubation(T1),the end of surgery(T2)and post-extubation(T3),cardiovascular stress indicators(norepinephrine(NE),dopamine(DA))at 1 day and 3 days after surgery and the incidence rates of adverse reactions were compared between the two groups.Results The awakening time after entering the operating room and the dosage of propofol in the esmolol group((18.73±2.56)min and(735.23±123.86)mg)were lower than(20.16±2.84)min and(807.35±146.50)mg in the control group,and the differences were statistically significant(t=2.897,P=0.004;t=2.912,P=0.004).There was no significant difference in anesthesia time between the esmolol group and the control group((3.41±0.43)h vs(3.29±0.37)h)(t=1.639,P=0.104).The HR,MAP and RPP in the esmolol group and the control group increased initially and then decreased.The HR,MAP and RPP of the esmolol group were lower than those of the control group at T1--T3,and the inter-group,time and interaction differences of all indicators were statistically significant(all P<0.05).Both ET and TXB2 levels showed an upward trend in the esmolol group and the control group.ET levels in the esmolol group were lower than those in the control group at T1-T3,and the inter-group,time and interaction differences were statistically significant(all P<0.05).TXB2 levels in the esmolol group were lower than those in the control group at T1-T2,and the inter-group,time and interaction differences were statistically significant(all P<0.05).The levels of NE and DA at 3 days after surgery in the esmolol group((321.51±41.33)pg/mL and(378.59±47.28)pmol/mL)were lower than(349.26±45.87)pg/mL and(410.52±52.14)pmol/mL in the control group(t=3.481,3.514,both P<0.001).There was no statistical significance in the total incidence rate of adverse reactions between the control group and the esmolol group(3.33%(2/60)vs 10.00%(6/60),χ2=1.205,P=0.272).Conclusion Esmolol can effectively stabilize hemodynamics during general anesthesia in elderly patients undergoing radical resection of colorectal cancer,improve stress response,with a good safety profile.
Keywords：radical resection of colorectal canceresmololmyocardial injuryhemodynamicsanesthesia quality
Publication Date：2026-03-25
Online Publishing Date：2026-04-07(First online date of this platform, not the publication date of the document)
Pages：5( 432-436 )