Efficacy of procaterol combined with theophylline sodium glycinate in the treatment of acute asthma exacerbation
CHEN Gang
ZHAO Songyun
ZHU Zhenzhen
Abstract：Objective To investigate the efficacy of procaterol combined with theophylline sodium glycinate in treatment of acute exacerbations of bronchial asthma(BA)and observe its impact on the host immune microenvironment.Methods A total of 100 patients with acute exacerbations of BA who were treated in The Second Naval Hospital of South-ern Theater Command of PLA between March 2021 and March 2024 were enrolled in the study and randomly divided into the control group and the observation group,with 50 cases in each group.The control group was treated with theophylline sodium glycinate and the observation group was given procaterol combined with theophylline sodium glycinate.Both groups were treat-ed for 2 consecutive weeks.The time of remission of clinical symptoms,pulmonary function indexes,fractional exhaled nitric oxide(FeNO),serum inflammatory cytokines,immune function indexes and incidence rates of adverse reactions were compared between the two groups.Results The time of remission of wheezing,chest tightness and cough of the observation group was(3.12±1.34),(3.45±1.41)and(3.87±1.16)d after treatment,shorter than(5.39±1.64),(4.66±1.28)and(5.11±1.49)d of the con-trol group(t=7.579,4.493,4.643,all P<0.001).The forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),FEV1/FVC ratio and peak expiratory flow(PEF)of the two groups were greater after treatment than those before treat-ment,and the above indexes of the observation group were(3.46±0.92)L,(4.19±1.14)L,(82.39±9.97)%and(4.99±1.36)L/s,respectively,higher than(2.68±0.85)L,(3.51±0.96)L,(76.44±9.56)%and(4.05±1.12)L/s of the control group(t=-4.403,-3.226,-3.046,-3.773,all P<0.05).The FeNO levels of the two groups were lower after treatment than those before treat-ment;the FeNO level of the observation group was(30.56±4.91)ppb,lower than(38.79±5.36)ppb of the control group(t=8.006,P<0.001).The levels of interleukin-6(IL-6)and tumor necrosis factor-alpha(TNF-α)of the observation group were(63.84±5.86)and(65.99±7.04)pg/mL,respectively,lower than(74.12±6.39)and(87.52±8.75)pg/mL of the control group(t=8.384,13.556,both P<0.001),and the IL-10 level of the observation group was(73.81±6.97)pg/mL,higher than(56.41±5.18)pg/mL of the control group(t=-14.168,P<0.001).The percentages of CD3+T cells and CD4+T cells as well as the CD4+/CD8+ratio of the observation group were(60.25±6.24)%,(40.88±3.54)%and(1.75±0.32)after treatment,higher than(50.83±6.05)%,(33.54±2.96)%and(1.21±0.21)of the control group(t=-7.664,-11.248,-9.976,all P<0.001),and the percentage of CD8+T cells of the observation group was(23.35±2.25)%,lower than(27.61±2.87)%of the control group(t=8.260,P<0.001).The incidence of adverse reactions was 6.00%(3/50)in the observation group,lower than 14.00%(7/50)in the control group,and there was no statistically significant difference(χ2=1.778,P=0.182).Conclusion The combination of procaterol and theophylline sodium glycinate demonstrates significant efficacy in the treatment of the patients with acute exacerbations of BA,effectively alleviating the symptoms,improving the pulmonary function,inhibiting the airway inflammation and modulating the immune microenvironment.
Keywords：bronchial asthmaprocateroltheophylline sodium glycinateacute exacerbationimmune function
Publication Date：2026-03-25
Online Publishing Date：2026-04-07(First online date of this platform, not the publication date of the document)
Pages：5( 396-400 )