Efficacy of tirofiban combined with mechanical thrombectomy and intravenous thrombolysis with rt-PA in the treatment of acute cerebral infarction
HE Changqing
LI Chunmei
LIU Jingchuan
WU Yinglei
LI Zhiyong
SUN Suwei
SUN Xia
ZHAO Jinxiao
WANG Dong
QIU Huijuan
Abstract：Objective To investigate the efficacy and safety of tirofiban combined with mechanical thrombectomy and intravenous thrombolysis with recombinant tissue-type plasminogen activator(rt-PA)in patients with acute cerebral infarc-tion(ACI).Methods A total of 118 patients with ACI admitted to Xingtai Central Hospital from August 2022 to June 2025 were selected and divided into the observation group(n=59)and the control group(n=59)according to the random number table method.The control group received mechanical thrombectomy combined with rt-PA intravenous thrombolysis,and the observation group received tirofiban combined with mechanical thrombectomy and rt-PA intravenous thrombolysis.Both groups were treated for 2 weeks.The clinical efficacy,levels of inflammatory factors and vascular endothelial function indicators,National Institutes of Health Stroke Scale(NIHSS)scores,modified Rankin Scale(mRS)scores,short-term prognosis,and incidence of adverse reactions between the two groups were compared.Results The total effective rate was 94.92%(56/59)in the observation group,higher than 83.05%(49/59)in the control group(χ2=4.236,P<0.05).After treatment,the levels of C-reactive protein,interleukin-6,and tumor necrosis factor-α in the observation group((7.36±0.87)mg/L,(25.32±7.64)pg/mL,and(15.43±5.33)pg/mL)were all lower than those in the control group((9.14±1.13)mg/L,(32.51±8.22)pg/mL,and(21.80±6.15)pg/mL)(t=9.587,4.921,6.012,all P<0.05).After treatment,the levels of nitric oxide and vascular endothelial growth factor in the observation group((62.11±7.69)μmol/L and(304.28±31.25)pg/mL,respectively)were higher than those in the control group((58.48±6.24)μmol/L and(261.21±23.82)pg/mL,respectively),while the level of endothelin-1((33.32±5.21)pg/mL)was lower than that in the control group((41.25±6.38)pg/mL)(t=2.816,8.419,7.395,all P<0.05).After treatment,the NIHSS scores((7.22±0.76)points)and mRS scores((1.24±0.32)points)in observation group were lower than that in control group((9.36±1.45)points and(1.55±0.34)points,respectively)(t=10.041,5.100,both P<0.05).The rate of favorable prognosis was 71.19%(42/59)in observation group,higher than 52.54%(31/59)in con-trol group(χ2=4.346,P<0.05).The incidence of adverse reactions was 11.86%(7/59)in the observation group and 8.47%(5/59)in the control group,showing non-statistically significant difference(χ2=0.371,P>0.05).Conclusion Tirofiban combined with me-chanical thrombectomy and rt-PA intravenous thrombolysis is effective in treating ACI patients.It significantly reduces the levels of inflammatory factors,effectively improves vascular endothelial function,promotes the recovery of neurological function,enhances short-term prognosis,and demonstrates a good safety profile.
Keywords：acute cerebral infarctiontirofibanmechanical thrombectomyrecombinant tissue-type plasminogen acti-vatorintravenous thrombolysis
Publication Date：2026-03-25
Online Publishing Date：2026-04-07(First online date of this platform, not the publication date of the document)
Pages：5( 344-348 )