Pareto analysis of 271 cases of adverse drug reactions to antineoplastic agents

DING Huan; YAO Wei; QIN Xiaowen; ZHANG Hong; LIU Hua; DING Yanni; LIANG Hai

doi:10.3969/j.issn.1672-8157.2026.02.030

Abstract：Objective To analyze the occurrence characteristics of adverse drug reactions(ADRs)to antineoplastic agents using Pareto method to identify key influencing factors,providing evidence for clinical safe medication.Methods A retrospective data analysis was adopted.A total of 271 reports of anti-tumor ADR submitted by Bozhou Hospital Affiliated to Anhui Medical University from January 2022 to May 2025 were collected.The Pareto method was used to statistically ana-lyze the patients'age,gender,administration route,drug type,involved system/organ,occurrence time and outcome of ADRs.Results Among the patients reported by ADRs,54.61%(148/271)were female and 45.39%(123/271)were male.The age group distribution was mainly 55～64 years old(31.37%,85/271),65～74 years old(29.52%,80/271),and 75～84 years old(18.08%,49/271).Intravenous infusion was the main route of administration(94.46%,256/271).The top three drugs causing ADRs were paclitaxel(28.41%,77/271),cisplatin(16.97%,46/271),and oxaliplatin(9.23%,25/271).Damage to the blood and hematopoietic system accounted for the highest proportion(68.63%,186/271),followed by gastrointestinal reactions(25.46%,69/271).ADR occurred mainly at 1～2 days,3～7 days,8～15 days and 16～30 days after medication,with a cumulative proportion of 78.97%(214/271).The proportion of physicians among the reported personnel was 96.31%(261/271).All ADRs improved or recovered after intervention.Conclusion Antineoplastic drug-related ADRs demonstrate distinct temporal patterns,drug-spe-cific risks,and age-related characteristics.Enhanced surveillance should be prioritized for high-risk populations,critical time periods,and specific medications,coupled with optimized multidisciplinary reporting mechanisms to improve medication safety.