Clinical evaluation of Compound Huangbai Liquid combined with cefuroxime sodium in patients after hemorrhoidectomy
ZHANG Ling
LIU Yongming
ZHANG Xiuling
YANG Guang
Abstract：Objective To investigate the effects of Compound Huangbai Liquid combined with cefuroxime sodium on wound healing and inflammatory levels in patients after hemorrhoidectomy.Methods A prospective randomized controlled study design was adopted.A total of 312 patients who underwent hemorrhoidectomy at the No.4 People's Hospital of Hengshui from October 2023 to March 2025 were selected and randomly divided into the observation group and the control group using a random number table method,with 156 cases in each group.Both groups received routine symptomatic treatment and anti-in-fective therapy with cefuroxime sodium postoperatively.The observation group additionally received Compound Huangbai Liquid lotion for sitz baths.After 2 weeks of treatment,clinical efficacy,wound healing time,wound edema,Visual Analogue Scale(VAS)pain scores,serum levels of inflammatory factors(tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)),and the incidence of complications were compared between the two groups.Results The observation group showed higher disease control rate(90.39%(141/156)vs 76.93%(120/156))and edema control rate(79.49%(124/156)vs 6.79%(73/156))compared to the control group(χ²=10.337,35.820,both P<0.001).The wound healing time was significantly shorter in the observation group than in the control group((16.19±3.52)days vs(20.33±4.47)days,t=9.088,P<0.001).On day 3 and day 7 after treatment,VAS scores were lower in the observation group than those in the control group(t=4.631,14.144,both P<0.001).Repeated measures analysis of variance showed statistically significant effects in VAS scores across groups,over time,and in interaction effects.(F_group=15.632,P<0.001;F_time=125.367,P<0.001;F_interaction=85.214,P<0.001).The observation group also exhibited signifi-cantly lower levels of TNF-α((3.12±0.41)ng/mL vs(4.05±0.65)ng/mL,t=15.114,P<0.001)and IL-6((12.49±3.63)ng/mL vs(15.63±4.67)ng/mL,t=6.630,P<0.001)compared to the control group.The incidence of complications in the observa-tion group was significantly lower than that in the control group(8.33%(13/156)vs 18.59%(29/156),χ²=7.043,P<0.05).Conclusion The addition of Compound Huangbai Liquid to conventional antibiotic therapy after hemorrhoidectomy can sig-nificantly promote wound healing,alleviate pain and edema,reduce inflammatory response,lower complications,with a good safety and efficacy profile.
Keywords：Compound Huangbai Liquidhemorrhoidectomyantibiotic therapymixed hemorrhoidspostoperative healinginflammation levels
Publication Date：2026-02-25
Online Publishing Date：2026-03-16(First online date of this platform, not the publication date of the document)
Pages：5( 286-290 )