Comparison of the efficacy of arotinolol and propranolol in the treatment of cirrhotic portal hypertension
GUO Hao
LI Yanru
DUAN Hualing
LI Chen
MAO Jianna
WANG Yunxi
Abstract：Objective To compare the application effect of arotinolol and propranolol on patients with cirrhotic portal hypertension.Methods A prospective controlled study design was adopted.A total of 86 patients with cirrhotic por-tal hypertension admitted to the Xinxiang Central Hospital from January 2021 to October 2024 were selected as test subjects and divided into two groups according to the random number table method.The two groups were treated with arotinolol(the arotinolol group,n=43)and propranolol(the propranolol group,n=43),respectively.The changes of portal vein flow velocity,hepatic vein damping index,nitric oxide,endothelin-1,angiopoietin-2,vascular endothelial growth factor,soluble cluster of differentiation 163,interleukin-6,alanine aminotransferase and aspartate aminotransferase,as well as treatment safety and the rate of gastrointestinal bleeding were observed in the two groups after treatment.Results The portal vein flow velocity in the arotinolol group was(18.71±3.51)cm/s,higher than(15.78±3.66)cm/s in the propranolol group(t=3.789,P<0.05),while the hepatic vein damping index was(0.60±0.08)in the arotinolol group,lower than(0.66±0.11)in the propranolol group(t=2.627,P<0.05).The level of nitric oxide was(79.74±11.11)μmol/L in the arotinolol group,higher than(74.55±10.21)μmol/L in the propranolol group(t=2.254,P<0.05),while the level of endothelin-1 was(58.10±9.16)pg/mL in the arotinolol group,lower than(63.67±9.27)pg/mL in the propranolol group(t=2.803,P<0.05).There were no statistically significant differences in the levels of angiopoietin-2 and vascular endothelial growth factor between the two groups(t=1.745,1.523,both P>0.05).The levels of soluble cluster of differentiation 163 and interleukin-6 in the arotinolol group were(2.01±0.41)ng/mL and(30.57±8.23)pg/mL,lower than(2.33±0.40)ng/mL and(35.42±10.61)pg/mL in the propranolol group(t=3.622,2.370,both P<0.05).The levels of alanine aminotransferase and aspartate aminotransferase were(66.32±9.02)and(65.09±8.40)U/L in the arotinolol group,which were not statistically different from(67.55±8.65)and(66.69±11.09)U/L in the propranolol group(t=0.646,0.752,both P>0.05).There were no statistically significant differences in treatment safety(13.95%vs 18.60%)and the rates of gastroin-testinal bleeding(9.30%vs 16.28%)between the arotinolol group and the propranolol group(χ2=0.341,0.938,both P>0.05).Conclusion Both arotinolol and propranolol can improve portal vein hemodynamics and vascular endothelial function,and inhibit inflammation in patients with cirrhotic portal hypertension.However,arotinolol demonstrates superior efficacy in enhanc-ing portal vein hemodynamics and vascular endothelial function.
Keywords：cirrhosisportal hypertensionarotinololpropranololvascular endothelial function
Publication Date：2026-02-25
Online Publishing Date：2026-03-16(First online date of this platform, not the publication date of the document)
Pages：5( 252-256 )