Analgesic effect of lidocaine combined with celecoxib after anterior cruciate ligament reconstruction
WANG Min
ZHANG Yingkai
CAI Guoping
Abstract：Objective To investigate the effects of lidocaine combined with celecoxib on postoperative pain and joint function in patients with anterior cruciate ligament(ACL)rupture and meniscus injury scheduled for arthroscopic reconstruction surgery.Methods A total of 132 patients with unilateral ACL rupture and meniscus injury scheduled for arthroscopic recon-struction at Jinshan Hospital ofFudan University from March 2022 to February 2025 were enrolled and randomly assigned to the combination group(n=66,receiving lidocaine plus celecoxib)and the celecoxib monotherapy group(n=66,receiving celecoxib alone).The Numerical Rating Scale(NRS),Sleep Interference Scale(SIS),knee function scores,postoperative complications,and analgesic rescue situation were recorded at baseline(T0)and at 1 day,7 days,14 days,1 month,and 3 months postoperatively(T1-T5).Results At 1,7,and 14 days,1 month and 3 months post-medication,NRS scores in both groups were lower than those before medication(all P＜0.05),and the scores in the combination group((3.67±0.75),(2.04±0.63),(1.57±0.50),(1.49±0.48),and(0.69±0.22)points,respectively)were lower than those in the celecoxib monotherapy group((4.21±0.83),(2.65±0.77),(2.18±0.67),(1.91±0.45),and(1.34±0.30)points,respectively)(t=3.922,4.981,5.928,5.186,14.194,all P＜0.05).At 14 days,1 and 3 months post-medication,SIS scores in the combination group((4.84±1.10),(3.71±0.87),(2.89±0.91)points)were signifi-cantly lower than those in the celecoxib monotherapy group((6.37±1.32),(5.28±0.99),(4.13±1.07)points)(t=7.234,9.678,7.172,all P＜0.05).After 2 weeks of medication,knee joint scores and functional activity scores in both groups were significantly higher than those before medication(all P＜0.05),and the scores in the combination group((75.30±3.51),(47.32±5.49)points,respec-tively)were higher than those in the celecoxib monotherapy group((72.20±3.44),(45.28±5.21)points,respectively)(t=5.124,2.190,both P＜0.05).The incidence of postoperative complications did not differ significantly between the two groups(9.09％(6/66)vs 15.15％(10/66);x2=l.138,P＞0.05).The combination group required less rescue analgesia within 2 weeks(7.58％(5/66)vs 19.70％(13/66);x2=4.117,P＜0.05)and had a longer time to first rescue analgesia((33.56±2.72)h vs(31.29±2.33)h,t=5.149,P＜0.05).Conclusion The combination of lidocaine and celecoxib for patients undergoing ACL reconstruction com-bined with meniscus repair significantly reduces postoperative pain intensity in both early and medium-to long-term,alleviates pain-related sleep disturbances,promotes knee joint functional recovery,decreases the postoperative rescue analgesia rate,and does not increase the incidence of postoperative complications,demonstrating a favorable safety profile.
Keywords：lidocainecelecoxibknee arthroscopyanterior cruciate ligament rupturemeniscus injurypostoperative painjoint function
Publication Date：2026-01-25
Online Publishing Date：2026-03-03(First online date of this platform, not the publication date of the document)
Pages：5( 47-51 )