Analgesic efficacy of butorphanol combined with ropivacaine in transversus abdominis plane block for postoperative pain management following laparoscopic surgery
XU Zheng
QI Sumin
KONG Jing
Abstract：Objective To investigate the effect of butorphanol combined with ropivacaine transversus abdominis plane(TAP)block on postoperative pain in patients undergoing laparoscopic salpingectomy(LS).Methods A total of 96 pa-tients scheduled for TAP block combined with general anesthesia for LS at Xinrui Hospital,Xinwu District,Wuxi,from January 2023 to December 2024 were prospectively selected and divided into two groups using a random number table:the BR group(butorphanol combined with ropivacaine)and the R group(ropivacaine alone),with 48 cases in each group.The R group received TAP block with 0.25％ropivacaine,while the BR group received TAP block with 0.25％ropivacaine plus 1 mg butorphanol.Visual Analog Scale(VAS)scores at different postoperative time points(T1-T5:2,6,12,24,and 48 hours postoperatively),analgesic consumption within 24 hours postoperatively,number of effective button presses on the patient-controlled analgesia pump,time to first postoperative flatus,time to first postoperative ambulation,length of hospital stay,Quality of Recovery-40(QoR-40)score at 24 hours postoperatively,and the incidence of adverse reactions were compared between the two groups.Results VAS scores at 2,6,12,24,and 48 hours postoperatively in the BR group were lower than those in the R group((1.26±0.26)points vs(1.47±0.33)points,(1.74±0.48)points vs(2.01±0.54)points,(2.41±0.66)points vs(2.83±0.74)points,(2.28±0.51)points vs(2.56±0.57)points,(1.50±0.39)points vs(1.76±0.41)points)(t=3.463,2.589,2.935,2.536,3.183,all P＜0.05).Sufentanil consump-tion and the number of effective button presses on the PCA pump within 24 hours postoperatively were lower in the BR group than those in the R group((76.01±9.54)μg vs(83.98±9.71)μg,(6.05±1.75)times vs(8.88±1.64)times)(t=4.056,8.175,both P＜0.001).Time to first flatus,time to ambulation,and length of hospital stay were shorter in the BR group,and the QoR-40 score was higher compared to the R group((12.83±1.79)h vs(14.39±1.93)h,(2.76±0.76)d vs(3.11±0.91)d,(7.32±1.14)d vs(8.06±1.27)d,(181.05±9.25)points vs(174.42±10.14)points)(t=4.106,2.045,3.004,3.347,all P＜0.05).There was no statis-tically significant difference in the incidence of adverse reactions between the two groups(12.50％(6/48)vs 14.58％(7/48),x2=0.089,P＞0.05).Conclusion Butorphanol combined with ropivacaine TAP block can effectively reduce postoperative pain intensity in patients undergoing LS,decrease the dosage of sufentanil within 24 hours and the effective button presses on the PCA pump,promote first exhaust,early ambulation,and shorten hospital stay.It also significantly improves the quality of post-operative recovery without increasing the incidence of adverse reactions.
Keywords：butorphanolropivacainetransversus abdominis plane blocklaparoscopic salpingectomypostoperative painmultimodal analgesia
Publication Date：2026-01-25
Online Publishing Date：2026-03-03(First online date of this platform, not the publication date of the document)
Pages：5( 37-41 )