The preemptive analgesic effect of celecoxib combined with tizanidine in patients undergoing lumbar endoscopic surgery
TENG Jiaxuan
JIANG Yi
ZHAO Jin
FANG Qiuyuan
YUAN Shuai
Abstract：Objective To observe the preemptive analgesic effect of celecoxib combined with tizanidine in patients undergoing endoscopic lumbar spine surgery.Methods This prospective randomized controlled trial enrolled patients scheduled for surgical treatment of lumbar disc herniation at Beijing Haidian Hospital between March and November 2023.Participants were randomly assigned to the observation group and the control group(n=45 each)using a random number table method.The observation group received oral celecoxib(200 mg)and tizanidine(2 mg)the night before and on the morning of surgery.The control group received oral celecoxib(200 mg)the night before and on the morning of surgery.The rescue analgesia within 48 hours after surgery,Visual Analogue Scale(VAS)scores at rest and during activity,the pain intensity classification,vital signs and adverse reactions of the two groups were observed.Results Within 48 hours postoperatively,the observation group demonstrated a significantly lower rescue analgesia rate(55.55％(25/45)vs 77.78％(35/45),x2=5.000,P＜0.05),fewer rescue analgesic episodes((1.66±0.35)times vs(1.97±0.42)times,t=-3.804,P＜0.001),and a lower total rescue analgesic dosage((161.25±30.58)mg vs(188.41±38.94)mg,t=-3.680,P＜0.001)compared to the control group.At 48 and 72 hours postoperatively,the VAS scores for pain during the rest and activity phases in the observation group were significantly lower than those in the control group((1.2±0.4),(1.9±0.4),(1.7±0.4),(2.0±0.6)points vs(1.9±0.6),(2.3±0.5),(2.6±0.8),(2.9±0.9)points,respectively),with statistically significant differences(t=-6.512,-4.191,-6.750,-5.582,all P＜0.05).At 48 and 72 hours postoperatively,the proportions of patients with VAS scores＞3 in the observation group(11.11％(5/45)and 17.78％(8/45),respectively)were lower than those in the control group((33.33％(15/45)and 48.89％(22/45),respectively),with statistically significant differences(x2=6.629,9.800,both P＜0.05).The incidence rates of adverse reactions within 48 hours after surgery were 6.67％(3/45)in the observation group and 4.44％(2/45)in the control group,and the difference was not statistically significant(x2=0.000,P＞0.05).Conclusion The preemptive analgesic regimen of celecoxib combined with tizanidine provides effective postoperative pain relief with a favorable safety profile for patients undergoing lumbar endoscopic surgery.
Keywords：celecoxibtizanidinepreemptive analgesiapercutaneous lumbar endoscopic discectomy
Publication Date：2026-01-25
Online Publishing Date：2026-03-03(First online date of this platform, not the publication date of the document)
Pages：5( 32-36 )