Application evaluation of remimazolam combined with remifentanil for non-intubated general anesthesia in ureteral stent removal
CUI Peng
ZHOU Biao
SUN Jia
ZHENG Shao
HE Nana
QI Xunze
HU Jie
Abstract：Objective To investigate the safety and efficacy of remimazolam combined with remifentanil for non-intubated general anesthesia in ureteral stent removal(USR).Methods A total of 86 patients undergoing USR at Luoy-ang Central Hospital between February 2023 and August 2024 were selected and randomly assigned via computer-generated random numbers to the observation group(n=43)and the control group(n=43).The control group received propofol combined with remifentanil,while the observation group received remimazolam combined with remifentanil for general anesthesia main-tenance.Mean arterial pressure(MAP),heart rate(HR),and pulse oxygen saturation(SpO2)were compared between the two groups at different time points:before anesthesia(T1),during urethral insertion of the cystoscope(T2),during stent removal(T3),upon entering the post-anesthesia care unit(PACU)(T4),and upon leaving the PACU(T5).Anesthesia induction time,op-erative time,recovery time,PACU stay duration,and the incidence of adverse reactions were also compared between the two groups.Results The MAP in the observation group at T1,T2,T3,T4,and T5 were(91.49±7.04),(87.32±7.06),(85.21±6.89),(88.19±6.48),and(89.14±7.29)mmHg(1 mmHg=0.133 kPa),respectively,while those in the control group were(92.16±7.20),(84.26±6.77),(80.58±6.39),(83.07±6.44),and(88.70±6.24)mmHg,respectively.There were statistically significant time effects,interaction effects,and intergroup differences in MAP between the two groups of USR patients(Ftime=21.648,Finteraction=2.985,Fgroup=15.7 86,all P＜0.05).The HR of the observation group at T1,T2,T3,T4,and T5 were(75.23±8.49),(73.89±8.08),(71.28±5.25),(72.53±6.44),and(73.70±6.18)beats/min,respectively,while those of the control group were(75.34±9.63),(70.33±8.18),(64.16±5.58),(68.35±5.47),and(72.26±6.54)beats/min,respectively.There were statistically sig-nificant time effects,interaction effects,and intergroup differences in HR between the two groups of USR patients(Ftime=13.361,Finteraction=3.200,Fgroup=23.378,all P＜0.05).The SpO2 in the observation group at T1,T2,T3,T4,and T5 were(98.54±6.33),(98.49±5.34),(97.89±6.02),(98.62±5.67),and(99.13±3.60)％,respectively,while those in the control group were(97.21±6.12),(96.11±5.49),(95.09±6.08),(96.79±5.78),and(98.73±4.10)％,respectively.There was no statistically significant time effect or interaction effect on SpO2 in the two groups of USR patients(Ftime=2.253,Finteraction=0.625,both P＞0.05),while the between-group effect showed statistical significance(Fgroup=10.351,P＜0.05).Awakening time((3.15±1.21)min vs(3.86±1.52)min)and PACU stay time((30.12±6.03)min vs(32.87±6.09)min)were both shorter in the observation group than in the control group(t=2.396,2.104,both P＜0.05).The incidence of adverse reactions was 4.65％(2/43)in the observation group and 11.63％(5/43)in the control group,with no statistically significant difference(Fisher's exact probability test,P=0.438).Conclusion The use of remimazolam combined with remifentanil for general anesthesia maintenance in patients undergoing USR provides stable hemo-dynamics,shortens recovery and PACU stay times,and does not increase the incidence of adverse reactions.
Keywords：remimazolamremifentanilnon-intubated general anesthesiaureteral stent removalclinical research
Publication Date：2026-01-25
Online Publishing Date：2026-03-03(First online date of this platform, not the publication date of the document)
Pages：5( 27-31 )