Efficacy of Zishen Yutai Pills combined with dydrogesterone tablets in the treatment of patients with unexplained recurrent spontaneous abortion
ZHANG Lijun
ZHOU Li
Abstract：Objective To explore the efficacy of Zishen Yutai Pills combined with dydrogesterone tablets on the pregnancy outcome and the levels of estrogen and progesterone in patients with unexplained recurrent spontaneous abortion.Methods A total of 82 patients with unexplained recurrent spontaneous abortion treated at the First Affiliated Hospital of Henan University of Chinese Medicine from January 2022 to October 2024 were retrospectively selected.Patients were assigned to the two groups according to the treatment plan:the dydrogesterone group(n=39,received standard intervention plus dydrogesterone tablets)and the combined group(n=43,received standard intervention plus dydrogesterone tablets and Zishen Yutai Pills).Both groups began drug treatment immediately upon enrollment and continued until 12 weeks of gestation or two weeks after the latest miscarriage event.The pregnancy outcomes(full-term delivery,survival of preterm infants,miscarriage,successful pregnancy maintenance),hormone levels(human chorionic gonadotropin,estradiol,progesterone),and traditional Chinese medicine(TCM)syndrome scores before and after treatment were compared.Results The success rate of miscarriage prevention in the combined group was 83.72%(36/43),higher than 58.97%(23/39)in the dydrogesterone group,with a statistically significant difference(χ2=6.206,P=0.013).After treatment,serum human chorionic gonadotropin(hCG),estradiol,and progesterone levels increased in both the dydrogesterone and the combined groups,and the levels of serum hCG,estradiol in the combined group((112 576.79±569.83)IU/L and(497.22±74.58)ng/L,respectively)were higher than those in the dydrogesterone group((85 430.10±543.06)IU/L and(415.18±62.27)ng/L,respectively),with statistically significant differences(t=220.296,5.376,both P＜0.05).After treatment,the progesterone levels between the two groups showed no statistically significant difference(t=1.954,P＞0.05).After treatment,both the dydrogesterone group and the combined group showed decreases in the primary and secondary symptom scores and total scores of TCM syndromes compared to before treat-ment.Furthermore,the above scores in the combined group((11.94±1.78)points,(5.76±0.87)points,and(17.70±1.59)points,respectively)were lower than those in the dydrogesterone group((16.36±2.45)points,(8.29±1.23)points,and(24.65±2.28)points,respectively),with statistically significant differences(t=9.407,10.830,16.131,all P＜0.05).Conclusion The combination of Zishen Yutai Pills and dydrogesterone tablets can improve the success rate of miscarriage prevention in patients with unexplained recurrent spontaneous abortion,effectively regulate hormone levels,and improve TCM syndromes.
Keywords：unexplained recurrent spontaneous abortionZishen Yutai Pillsdydrogesterone tabletsmiscarriage pre-vention effectestrogen and progesterone
Publication Date：2025-12-25
Online Publishing Date：2026-01-07(First online date of this platform, not the publication date of the document)
Pages：4( 1580-1583 )