Clinical evaluation of gabapentin combined with stellate ganglion block in patients with trigeminal postherpetic neuralgia
YAN Shaoyao
NIE Huiyong
YUAN Weili
WANG Suoliang
ZHANG Jia
Abstract：Objective To explore the efficacy of gabapentin combined with stellate ganglion block in the treat-ment of patients with trigeminal postherpetic neuralgia(TG-PHN)and its influence on pain,stress indicators and sleep quality.Methods A total of 90 patients with TG-PHN treated in the Department of Pain of the First Affiliated Hospi-tal of Xi'an Jiaotong University from March 2021 to March 2024 were recruited as the research subjects and random-ly divided into the observation group(45 cases)and the control group(45 cases)by the coin tossing method.The control group was treated with gabapentin combined with local injection of pain area,while the observation group received ga-bapentin combined with stellate ganglion block therapy.Visual analogue scale(VAS)was used to evaluate the pain de-gree in the two groups,and Pittsburgh Sleep Quality Index(PSQI)was adopted to assess the sleep quality of the two groups.Serum stress indicators(norepinephrine(NE),epinephrine(E),cortisol(Cor))and serum biochemical indicators(substance P(SP),β-endorphin(β-EP),calcitonin gene-related peptide(CGRP),chemokine ligand 10(CXCL-10),and neurokinin-1(NK-1))were detected for the two groups by ELISA.The adverse reactions of the two groups were recorded during treatment.Results The total effective rate of the observation group was higher than that of the control group after the treatment(93.33%(42/45)vs 77.78%(35/45))(χ2=4.406,P=0.036).The scores of VAS and PSQI and the levels of NE,E,Cor,SP,CGRP,CXCL-10 and NK-1 of the two groups were lower after the treatment than those before the treatment,while the β-EP level was lower after the treatment than that before the treatment(the control group:t=10.813,13.617,3.410,9.773,9.912,11.262,16.362,9.767,16.616,6.364,all P＜0.05;the observation group:t=15.868,14.473,14.492,15.151,16.649,24.022,26.814,12.836,16.452,11.512,all P＜0.05).The scores of VAS and PSQI((4.79±1.29)points vs(3.81±1.12)points,(9.23±1.66)points vs(8.41±2.10)points,t=3.848,2.055,both P＜0.05)and the levels of NE,E,Cor,SP,CGRP,CXCL-10 and NK-1(t=11.869,7.217,14.123,10.220,19.484,2.568,3.184,all P＜0.05)were lower in the observation group than those in the con-trol group after the treatment,while the β-EP level was higher in the observation group than that in the control group((20.20±3.00)pg/mL vs(26.01±4.98)pg/mL,t=6.704,P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups during the treatment(χ2=0.385,P=0.535).Conclusion Gabapentin combined with stellate ganglion block in the treatment of TG-PHN can effectively relieve pain symptoms,enhance sleep quality and reduce stress response.
Keywords：gabapentinstellate ganglion blocktrigeminal postherpetic neuralgiapainstress indicatorsleep quality
Publication Date：2025-12-25
Online Publishing Date：2026-01-07(First online date of this platform, not the publication date of the document)
Pages：5( 1555-1559 )