Effect of Bifidobacterium triple viable on gastrointestinal function and inflammation levels in patients undergoing coronary artery bypass grafting
ZHAO Li
ZHANG Chi
QI Leilei
WANG Jihong
GUO Lixin
Abstract：Objective To investigate the effects of Bifidobacterium triple viable on gastrointestinal function and inflammation levels in patients undergoing coronary artery bypass grafting(CABG).Methods A total of 126 patients who underwent CABG at Xingtai Central Hospital between September 2024 and July 2025 were prospectively selected and ran-domly allocated into the control group(n=63)and the observation group(n=63)using a random number table.The control group received conventional symptomatic treatment,while the observation group received conventional treatment plus Bifido-bacterium triple viable.Gastrointestinal function,nutritional status(total serum protein,albumin,prealbumin(PAB)),D-lac-tate level,white blood cell count and inflammatory cytokines(procalcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6),interleukin-10(IL-10))levels were compared between the two groups.Results The time to first flatus,first defeca-tion,and bowel sound recovery in the observation group((28.19±4.36)h,(30.23±5.24)h,(18.13±4.62)h,respectively)were shorter than those in the control group((34.61±4.71)h,(38.77±5.31)h,(23.14±4.53)h,respectively)(t=﹣7.939,﹣9.086,﹣6.146,all P＜0.05).The incidence of gastrointestinal dysfunction in the observation group was 11.11%(7/63),lower than 25.40%(16/63)in the control group(χ2=4.308,P＜0.05).Serum total protein and PAB levels in the observation group((77.39±5.88)g/L,(276.94±24.32)mg/L,respectively)were higher than those in the control group((69.31±5.78)g/L,(233.84±22.59)mg/L,respectively),while the D-lactate level in the observation group((0.58±0.15)mmol/L)was lower than that in the control group((0.75±0.18)mmol/L)(t=7.778,10.306,﹣5.789,all P＜0.05).The levels of PCT,CRP,IL-6,and white blood cell count in the observation group((62.13±10.34)ng/dL,(9.56±2.45)μg/mL,(8.13±2.17)pg/mL,(10.09±1.03)×109/L,respectively)were lower than those in the control group((66.81±10.51)ng/dL,(11.33±2.36)μg/mL,(11.94±2.35)pg/mL,(11.79±1.00)×109/L,respectively),while the IL-10 level in the observation group((12.07±3.41)pg/mL)was higher than that in the control group((10.49±3.33)pg/mL)(t=﹣2.519,﹣4.130,﹣9.454,﹣9.399,2.631,respectively,all P＜0.05).The hospital stay and time to initiate of enteral nutrition in the observation group((8.15±1.78)d,(24.17±4.56)h,respectively)were shorter than those in the control group((11.17±2.47)d,(36.36±6.27)h,respectively)(t=﹣7.873,﹣12.480,both P＜0.05).The incidence of com-plications in the observation group was 7.94%(5/63),lower than 25.40%(16/63)in the control group(χ2=6.914,P＜0.05).Conclusion Bifidobacterium triple viable can effectively improve gastrointestinal function and nutritional status in patients un-dergoing CABG,reduce damage to the intestinal mucosal barrier,and alleviate inflammatory responses.
Keywords：Bifidobacterium triple viablecoronary artery bypass graftinggastrointestinal functioninflammation lev-elnutritional status
Publication Date：2025-12-25
Online Publishing Date：2026-01-07(First online date of this platform, not the publication date of the document)
Pages：6( 1522-1527 )