Efficacy of atorvastatin combined with aspirin in the treatment of patients with hemiplegia after cerebral infarction

LI Jie; BAI Yongchun; ZHANG Zhaofeng

doi:10.3969/j.issn.1672-8157.2025.09.008

Abstract：Objective To explore the efficacy of atorvastatin combined with aspirin in the treatment of patients with hemiplegia after cerebral infarction.Methods This was a prospective study.A total of 62 patients with hemiplegia af-ter cerebral infarction treated in Huainan Xinhua Medical Group Xinhua Hospital from September 2022 to December 2024 were enrolled in the study and randomly divided into the control group with 31 cases and the observation group with 31 cases.The control group was treated with conventional therapy plus atorvastatin,and the observation group was given conventional therapy plus atorvastatin and aspirin.Both groups were treated for 3 months.The levels of blood lipids(low density lipopro-tein cholesterol(LDL-C),total cholesterol(TC),triglyceride(TG)),self-care ability(Barthel Index(BI)),mental state indexes(Mini-Mental State Examination(MMSE)scores),limb motor ability,the levels of platelet function-related indexes(platelet activating complex-1(PAC-1),platelet membrane surface P-selectin(CD62p))before and after treatment,and the incidence of adverse reactions were compared between the two groups.Results The levels of LDL-C,TC and TG of the observa-tion group were lower than those of the control group after treatment((2.57±0.38)mmol/L vs(2.86±0.37)mmol/L;(3.18±0.75)mmol/L vs(3.67±0.71)mmol/L;(1.28±0.23)mmol/L vs(1.43±0.22)mmol/L),and there were statistically significant dif-ferences(t=3.044,2.642,2.624,all P＜0.05).The BI score and MMSE score of the observation group were higher than those of the control group((75.35±5.67)points vs(70.12±5.11)points;(24.35±2.87)points vs(21.35±2.81)points),and there were statis-tically significant differences(t=3.815,4.159,both P＜0.05).The scores of upper limb motor ability and lower limb motor ability of the observation group were higher than those of the control group after treatment((45.35±4.67)points vs(41.38±4.61)points;(24.32±2.12)points vs(21.35±2.13)points),and there were statistically significant differences(t=3.368,5.503,both P＜0.05).The levels of PAC-1 and CD62p of the observation group were lower than those of the control group after treatment((6.78±1.35)%vs(8.54±1.32)%;(4.68±1.22)%vs(5.38±1.23)%),and there were statistically significant differences(t=5.190,2.250,both P＜0.05).The incidence of adverse reactions was 9.69%(3/31)in the observation group and 3.23%(1/31)in the control group,with no statistically significant difference(χ2=0.267,P=0.605).Conclusion Atorvastatin combined with aspirin can improve the blood lipids,mental state and platelet function,and enhance the self-care ability and limb motor function of the patients with hemiple-gia after cerebral infarction,demonstrating a favorable safety profile.