Efficacy of Gejie Dingchuan Pill combined with tiotropium bromide on patients with chronic obstructive pulmonary disease
WANG Xinyue
XU Minni
ZHU Juanjuan
Abstract：Objective To analyze the efficacy of Gejie Dingchuan Pill combined with tiotropium bromide in the treatment of elderly patients with chronic obstructive pulmonary disease(COPD).Methods A total of 104 elder-ly patients with COPD treated in Xi'an Hospital of Traditional Chinese Medicine from August 2021 to May 2024 were selected as the observation subjects,and were divided into the inhalant group(single number)and the combined group(double number)by simple randomization method(single-double number method),with 52 cases in each group.The in-halant group was treated with tiotropium bromide inhalant,and the combined group was added with Gejie Dingchuan Pill on the basis of the inhalant group.The pulmonary function indicators(forced vital capacity(FVC),peak expiratory flow(PEF)),disease severity(COPD assessment test(CAT)score),BODE index((body mass index(BMI),forced expiratory volume in one second(FEV1),modified Medical Research Council(mMRC),6-minute walking distance(6MWD)),blood gas indicators(partial pressure of carbon dioxide in arterial blood(PaCO2),arterial oxygen saturation(SaO2),arterial hydrogen ion concentration(pH)),peripheral blood T lymphocyte subsets,B lymphocyte and natural killer(NK)cell were compared between the inhalant group and the combined group before and after treatment.The inci-dence of adverse reactions in the inhalant group and the combined group during treatment were statistically analyzed.Results After treatment,the FVC and PEF in the combined group((2.74±0.51)L and(2.61±0.76)L/s)were higher than(2.49±0.44)L and(2.24±0.71)L/s in the inhalant group,and the CAT score in the combined group((12.96±3.26)points)was lower than(16.42±3.78)points in the inhalant group,with statistically significant differences(t=2.676,2.565,4.998,all P<0.05).After treatment,the BMI,FEV1%and 6MWD in the combined group((21.83±1.88)kg/m2,(70.12±8.38)%and(428.09±72.13)m)were higher than(21.08±1.69)kg/m2,(65.51±7.51)%and(385.72±62.85)m in the inhalant group,and the mMRC and BODE index scores in the combined group((1.14±0.12)grade and(2.25±0.56)points)were lower than(1.59±0.21)grade and(3.38±0.83)points in the inhalant group,with statistically significant differences(t=2.139,2.954,3.194,13.416,8.138,all P<0.05).After treatment,the SaO2 and pH in the combined group((96.41±5.48)%and(7.21±0.22))were high-er than(92.84±4.32)%and(6.97±0.28)in the inhalant group,and the PaCO2 in the combined group((43.96±6.37)mmHg(1 mmHg=0.133 kPa))was lower than(47.88±6.89)mmHg in the inhalant group,with statistically significant differences(t=3.689,4.860,3.012,all P<0.05).After treatment,the levels of CD4+,CD3+,CD4+/CD8+,B lymphocyte and NK cell in the combined group((36.02±2.13)%,(64.96±4.03)%,(1.34±0.03),(16.32±4.02)%and(13.68±2.77)%)were all higher than(34.33±2.29)%,(62.12±3.66)%,(1.19±0.02),(14.34±3.21)%and(9.71±2.61)%in the inhalant group,and the CD8+cell ratio in the combined group((26.94±2.26)%)was lower than(31.11±3.04)%in the inhalant group,with statistically significant differ-ences(t=3.897,3.762,3.915,2.775,3.126,4.206,all P<0.05).During the treatment period,there was no significant difference in the incidence of adverse reactions between the inhalant group and the combined group(χ2=0.210,P=0.647).Conclusion Gejie Dingchuan Pill combined with tiotropium bromide can significantly improve the exercise tolerance and pulmonary function of elderly patients with COPD,and improve the body's immune function.In addition,it has significant efficacy and high safety.
Keywords：Gejie Dingchuan Pilltiotropium bromide inhalantelderlychronic obstructive pulmonary diseasepulmo-nary functionefficacy
Publication Date：2025-11-25
Online Publishing Date：2025-12-04(First online date of this platform, not the publication date of the document)
Pages：6( 1386-1391 )