Efficacy of modified Shengmai Powder combined with hydroxychloroquine sulfate in treating patients with Sjögren's syndrome of Qi-Yin deficiency syndrome
HUO Heshui
ZHAO Menglin
Abstract：Objective To investigate the clinical efficacy and underlying mechanisms of modified Shengmai Powder combined with hydroxychloroquine sulfate in patients with Sjögren's syndrome(SS)of Qi-Yin deficiency syndrome.Methods A total of 86 patients with SS of Qi-Yin deficiency syndrome admitted to Jiaozuo People's Hospital from January 2023 to June 2024 were enrolled and divided into two groups by random number table method.The control group(n=43)re-ceived hydroxychloroquine sulfate alone,while the combination group(n=43)received modified Shengmai Powder on the basis of hydroxychloroquine sulfate.The course of treatment was 12 weeks.Traditional Chinese medicine(TCM)syndrome scores,disease activity indices,immunological parameters,salivary/tear secretion function,and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the combined group was higher than that of the control group(88.37%vs 67.44%,χ2=5.472,P=0.019).After treatment,TCM syndrome score,European League Against Rheu-matism(EULAR)Sjögren's syndrome Disease Activity Index(ESSDAI),and EULAR SS Patient Reported Index(ESSPRI)were significantly lower in the combination group((16.95±4.86)points,(1.08±0.37)points,and(1.46±0.48)points,respective-ly)than those in the control group((25.21±6.15)points,(2.23±0.61)points,and(2.35±0.51)points)(t=6.910,10.570,8.333,all P<0.05).After treatment,the salivary flow rate and tear secretion in the combination group((2.14±0.52)mL/min and(13.56±2.87)mm/5 min)were higher than those in the control group((1.65±0.40)mL/min and(11.25±2.64)mm/5 min)(t=4.898,3.884,both P<0.05).After treatment,the levels of IgG,IgA,C-reactive protein,and erythrocyte sedimentation rate in the combination group((8.21±1.95)g/L,(3.94±1.08)g/L,(1.19±0.33)mg/L,and(18.23±7.95)mm/h)were lower than those in the control group((13.87±3.56)g/L,(4.56±1.30)g/L,(1.67±0.31)mg/L,and(24.69±6.81)mm/h)(t=9.143,2.406,6.952,4.047,all P<0.05).The inci-dence of adverse reactions in the combined group and the control group was 6.98%(3/43)and 11.63%(5/43),respectively,with no significant difference(χ2=0.138,P=0.710).Conclusion The combination of modified Shengmai Powder and hydroxychloroquine sulfate can effectively improve the clinical symptoms and immune inflammatory responses in patients with SS of Qi-Yin deficiency syndrome,demonstrating superior efficacy compared to hydroxychloroquine monotherapy and favorable safety.
Keywords：Shengmai PowderQi-Yin deficiencysjögren's syndromeintegration of traditional and western medicineimmunomodulation
Publication Date：2025-10-25
Online Publishing Date：2025-11-03(First online date of this platform, not the publication date of the document)
Pages：5( 1298-1302 )