Effect of desflurane and sevoflurane inhalation anesthesia on elderly patients undergoing lower extremity orthopedic surgery
LIU Junwu
CHEN Tingting
HE Hongxia
ZHOU Lei
LIU Zhongjun
ZHANG Shun
HUANG Fei
Abstract：Objective To explore the effect of desflurane and sevoflurane inhalation anesthesia on elderly patients undergoing lower extremity orthopedic surgery.Methods A total of 102 patients aged over 65 who were scheduled for lower extremity orthopedic surgery under general anesthesia in the Meishan People's Hospital from January 2022 to January 2024 were selected and divided into the desflurane group(n=51)and the sevoflurane group(n=51)by the random number table method.During the surgery,the desflurane group continuously inhaled 4.5%-5.5%desflurane and the sevoflurane group inhaled 1.5%-2.0%sevoflurane.The onset time of anesthesia and the time to reach anesthesia depth were counted between the two groups.The hemodynamics and Ramsay sedation scores of both groups were observed at the time of entering the operating room(T0),1 min after extubation(T1),10 min after extubation(T2)and 1 h after extubation(T3).The postoperative recovery quality and the incidence rates of adverse reactions were compared.The Mini-Mental State Examination(MMSE)scores were compared before the surgery and at 1,24 and 48 h after the surgery.Results The onset time of anesthesia and the time to reach anes-thesia depth in the desflurane group were(2.18±0.26)min and(8.59±2.06)min,shorter than(3.92±1.42)min and(9.55±2.75)min in the sevoflurane group(t=8.608,1.995,both P<0.05).The heart rate values in the sevoflurane group at T1,T2 and T3 were(85.67±1.52)beats/min,(84.23±1.74)beats/min and(79.63±1.75)beats/min,higher than(83.10±2.05)beats/min,(82.11±1.63)beats/min and(76.55±1.47)beats/min in the desflurane group(t=7.192,6.350,9.624,all P<0.05).The pulse oxygen saturation was(93.45±1.96)%in the desflurane group,lower than(95.73±1.81)%in the sevoflurane group at T1(t=6.103,P<0.05).The Ramsay sedation scores at T2 and T3 in the desflurane group were(3.27±1.23)points and(2.35±0.11)points,lower than(3.95±1.22)points and(2.52±0.20)points in the sevoflurane group(t=2.803,5.319,both P<0.05).The postoperative spontaneous breathing recovery time,wake-up eye opening time,orientation recovery time and extubation time in the desflurane group were(6.21±1.52)min,(13.27±2.10)min,(18.56±1.23)min and(15.72±2.01)min,significantly shorter than(7.56±1.23)min,(15.89±2.11)min,(22.17±2.16)min and(16.75±2.30)min in the sevoflurane group(t=4.931,6.285,10.372,2.408,all P<0.05).The MMSE scores at 1 and 24 h after the surgery in the desflurane group were(25.51±1.24)points and(28.67±0.47)points,higher than(22.17±1.35)points and(28.25±0.81)points in the sevoflurane group(t=13.012,3.203,both P<0.05).There was no statistically significant differ-ence in the incidence of adverse reactions within 1 h after the surgery between the desflurane group and the sevoflurane group(9.80%vs 11.76%)(χ2=0.102,P>0.05).Conclusion For elderly patients undergoing lower extremity orthopedic surgery,the effect of desflurane inhalation anesthesia is better than that of sevoflurane inhalation anesthesia,with faster anesthesia onset and more stable vital signs during recovery.It can effectively avoid short-term cognitive dysfunction and demonstrate good safety.
Keywords：desfluranesevofluranelower extremity orthopedic surgeryrecovery qualitycognitive function
Publication Date：2025-10-25
Online Publishing Date：2025-11-03(First online date of this platform, not the publication date of the document)
Pages：5( 1283-1287 )