Efficacy of Modified Dachaihu Decoction combined with dapagliflozin in treating early diabetic kidney disease patients with qi deficiency and blood stasis syndrome
Yang Jinfeng
Li Junping
Fan Mengrong
Zhang Yun
Li Li
Ma Yiqing
Zhu Lingxiang
Abstract：Objective To explore the clinical efficacy of Modified Dachaihu Decoction combined with dapagliflozin in treating early diabetic kidney disease(DKD)with qi deficiency and blood stasis syndrome.Methods A total of 90 patients with early DKD who were treated at Rugao Bo'ai Hospital from January 2023 to September 2024 were selected and divided into the control group and the observation group according to a random number table method.The control group(45 cases)received conventional treatment combined with dapagliflozin tablets,and the observation group(45 cases)was additionally administered Dachaihu Decoction on the basis of the control group's treatment regimen.The treatment course for both groups was 12 weeks.The levels of blood glucose,oxidative stress and renal function were analyzed before treatment and after 12 weeks of treatment in both groups.The clinical effi-cacy and the incidence of adverse reactions were compared between the control group and the observation group.Results After 12 weeks of treatment,the levels of fasting blood glucose,glycated hemoglobin,malondialdehyde,urinary microalbumin,serum creatinine and urinary albumin excretion rate in the observation group((5.82±0.76)mmol·L-1,(6.58±0.47)%,(4.12±0.81)mmol·L-1,(45.79±5.41)mg·L-1,(92.58±9.37)μmol·L-1,(75.26±10.56)μg·min-1,respectively)were lower than those in the control group((6.85±0.87)mmol·L-1,(7.25±0.51)%,(5.76±1.03)mmol·L-1,(56.14±7.38)mg·L-1,(107.26±11.19)μmol·L-1,(97.63±13.25)μg·min-1,respectively),and the differences were statistically significant(t=5.981,6.481,8.396,7.588,6.747,8.857,all P<0.05).After 12 weeks of treatment,the superoxide dismutase level in the observation group((35.32±4.39)μmol·L-1)was higher than that in the control group((27.56±4.18)μmol·L-1),and the difference was statistically significant(t=8.588,P<0.05).The total effective rate in the control group(91.11%(41/45))was higher than that in the observation group(73.33%(33/45)),and the difference was statistically signifi-cant((χ2=4.865,P<0.05).No significant difference was observed in the incidence of adverse reactions between the two groups(15.56%(7/45)vs 11.11%(5/45))(χ2=0.385,P=0.535).Conclusion The Modified Dachaihu Decoction combined with dapagliflozin can effectively reduce blood glucose level in patients with early DKD with qi deficiency and blood stasis syndrome,improve oxidative stress levels and renal function,and have favorable clinical efficacy with good safety.
Keywords：Diabetic kidney diseaseQi deficiency and blood stasis syndromeModified Dachaihu DecoctionDapagliflozinRenal function
Publication Date：2025-09-25
Online Publishing Date：2025-10-10(First online date of this platform, not the publication date of the document)
Pages：5( 1133-1137 )