Clinical evaluation of Loulu Lianqiao Decoction in treating pediatric chronic rhinosinusitis

Wang Man; Wang Junge; Yan Xinyu; Zhao Jingyi; Meng Zhuo; Guo Suying

doi:10.3969/j.issn.1672-8157.2025.06.035

Abstract：Objective To discuss the application and clinical efficacy of Loulu Lianqiao Decoction in treating pediatric chronic rhinosinusitis(CRS).Methods A total 86 children with CRS who treated at the Department of Otorhinolaryngology,Beijing Hospital of Traditional Chinese Medicine(TCM),Capital Medical University from July 2024 to June 2025 were selected and divided into two groups using a computer-generated random number table.A total of 84 cases completed the observation and follow-up,with 42 cases in each of the Loulu Lianqiao group and the cefaclor group.The Loulu Lianqiao group received conventional basic therapy plus Loulu Lianqiao Decoction,while the cefaclor group received conventional basic therapy plus cefaclor dry suspension.Both groups were treat-ed for 14 days.TCM efficacy,visual analogue scale(VAS)scores,Sino-Nasal Outcome Test-20(SNOT-20)scores,nasal endoscopic Lund-Kennedy scores,total nasal resistance(TNR),safety,and adverse reactions were compared between the Loulu Lianqiao group and the cefaclor group before treatment,after treatment,and 14 days after drug withdrawal.Results TCM efficacy:At 14 days after drug withdrawal,the total effective rates were 92.86%(39/42)in the Loulu Lianqiao group and 88.10%(37/42)in the cefaclor group,with no statistically significant difference(χ2=0.380,P>0.05).However,the total marked effective rate in the Loulu Lianqiao group was significantly higher than that in the cefaclor group(66.67%(28/42)vs 35.71%(15/42);χ2=8.10,P=0.004).VAS scores:Both the Loulu Lianqiao group and the cefaclor group had lower VAS scores after treatment compared with those before treatment((6.96±2.08)points vs(1.95±1.18)points;(6.89±1.98)points vs(2.93±1.32)points),and the differences were statistically significant(all P<0.05).There were statistically significant differences between the two groups after treatment and 14 days after drug withdrawal(t=3.587,9.143;both P<0.05).Quality of life(SNOT-20):After treatment and at 14 days after withdrawal,both groups demonstrated significant lower SNOT-20 scores compared with those before treatment((12.76±3.55)points,(4.38±2.15)points,(4.67±1.92)points,(12.68±3.61)points,(5.75±2.34)points,(5.85±2.24)points,respectively),and the differences were statistically significant(all P<0.05).The Loulu Lianqiao group had significantly lower SNOT-20 scores than the cefaclor group both after treatment and at 14 days after withdrawal,and the differences were statistically significant(t=2.769,2.593,both P<0.05).There were no statistically significant differences between the Loulu Lianqiao group and the cefaclor group 14 days after drug withdrawal and the end of treatment(t=0.680,0.23,both P>0.05).Nasal endoscopic Lund-Kennedy scores:After treatment and 14 days after drug withdrawal,the scores in both the Loulu Lianqiao group and the cefaclor group were lower than those before treatment((6.26±1.72)points,(2.28±0.29)points,(2.07±0.30)points,and(6.47±1.51)points,(2.95±0.32)points,(2.45±0.33)points,respectively),and the differences were statistically significant(all P<0.05).After treat-ment and at 14 days after drug withdrawal,the Loulu Lianqiao group was superior to the cefaclor group,and the differences were statistically significant(t=10.075,5.53,both P<0.05).There were statistically significant differences in the scores 14 days after drug withdrawal compared with those at the end of treatment(t=25.1,20.7;both P<0.05).TNR values:The TNR values in the Loulu Lianqiao group and the cefaclor group after treatment and 14 days after drug withdrawal((0.42±0.18)Pa·(cm3·s)-1,(0.44±0.21)Pa·(cm3·s)-1,(0.65±0.20)Pa·(cm3·s)-1,(0.66±0.23)Pa·(cm3·s)-1,respectively)showed statistically significant differences compared with pre-treatment values((1.22±0.29)Pa·(cm3·s)-1,(1.25±0.32)Pa·(cm3·s)-1)in the same groups,and the differences were all statistically significant(all P<0.05).There were no statistically significant differences in TNR values 14 days after drug withdrawal compared with those after treatment(t=0.260,0.110,both P>0.05).No adverse reactions occurred in either group during treatment.Conclusion Loulu Lianqiao Decoc-tion demonstrates high clinical total marked effective rate in pediatric CRS,significantly improving nasal symptoms,subjective feelings,quality of life,and Lund-Kennedy endoscopic scores with good safety.