Efficacy of Xueshuantong injection combined with tenecteplase in elderly patients with large artery atherosclerotic ischemic stroke
Zheng Yuting
Feng Ting
Bai Rong
Gao Xinxin
Abstract：Objective To investigate the efficacy of Xueshuantong injection combined with tenecteplase in treatment of large artery atherosclerotic ischemic stroke(LAA)in elderly patients and its influence on serum lipoprotein-associated phospholipase A2(Lp-PLA2),monocyte chemoattractant protein-1(MCP-1)and neurological function.Methods A systematic retrospective analy-sis was conducted on the clinical records of 144 elderly patients with LAA who received treatment in the First Hospital of Yulin from January 2024 to May 2024.According to different treatment methods,patients treated with tenecteplase were included in control group(n=78),and those who were given Xueshuantong injection combined with tenecteplase therapy were enrolled as the combined group(n=66).The neurological status of the two groups before and after treatment was quantitatively evaluated by National Institutes of Health Stroke Scale(NIHSS).The levels of serum retinol binding protein 4(RBP4),Lp-PLA2 and MCP-1,coagulation function indicators(D-dimer(D-D),thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT))and neuro-logical function indicators(brain derived neurotrophic factor(BDNF),neuron-specific enolase(NSE),glial fibrillary acidic protein(GFAP))were observed in both groups before treatment and after 14 days of treatment,and the incidence rates of adverse reactions were counted in the two groups during medication.Results After 14 days of treatment,the NIHSS score and levels of RBP4,Lp-PLA2,MCP-1,NSE,GFAP and D-D in the combined group were(6.22±1.49)points,(15.11±5.34)mg·L-1,(121.86±17.46)μg·L-1,(121.24±11.27)μg·L-1,(9.21±1.47)μg·L-1,(3.51±0.98)ng·L-1 and(0.37±0.21)mg·L-1,which were lower than those of(7.07±2.07)points,(17.67±5.22)mg·L-1,(129.75±18.52)μg·L-1,(127.54±12.48)μg·L-1,(10.18±2.46)μg·L-1,(4.00±0.84)ng·L-1 and(0.56±0.52)mg·L-1 in the control group,and the differences were statistically significant(t=2.781,2.902,2.615,3.154,2.575,3.231,2.781,all P<0.05).The BDNF,TT,PT and APTT in combined group were(6.12±0.75)μg·L-1,(16.37±0.82)s,(14.51±1.07)s and(62.51±2.13)s after 14 days of treatment and they were higher than those of(5.72±0.74)μg·L-1,(15.92±0.96)s,(13.96±1.42)s and(61.55±2.01)s in the control group,and the differences were statistically significant(t=3.212,2.994,2.586,2.779,all P<0.05).Meanwhile,there were no statistical differ-ences in the incidence of adverse reactions between the two groups during the entire treatment period(P>0.05).Conclusion Xuesh-uantong injection combined with tenecteplase has exact efficacy in the treatment of LAA in elderly patients since it can improve neuro-logical function and regulate coagulation function.The mechanism of which may be related to the inhibitions of Lp-PLA2 and MCP-1.
Keywords：Xueshuantong injectionPanax notoginseng saponinsTenecteplaseLarge artery atherosclerotic ischemic strokeNeurological functionCoagulation function
Publication Date：2025-08-25
Online Publishing Date：2025-09-01(First online date of this platform, not the publication date of the document)
Pages：5( 909-913 )