Clinical evaluation of baoji oral liquid combined with omeprazole enteric-coated tablets in the treatment of patients with acute gastroenteritis
Zou Jiyuan
Wu Chen
Wang Hui
Chen Lin
Jiao Yuntao
Zuo Ruiju
Abstract：Objective To explore the efficacy of baoji oral liquid combined with omeprazole enteric-coated tablets in treatment of acute gastroenteritis and its influence on levels of gastrointestinal hormones,serum soluble interleukin-2 re-ceptor(sIL-2R),interleukin-2(IL-2)and C-reactive protein(CRP).Methods According to random number table method,106 patients with acute gastroenteritis admitted to Shunyi Hospital,Beijing Traditional Chinese Medicine Hospital were di-vided into the control group and the observation group,with 53 in each group.The patients in the control group were treated with omeprazole enteric-coated tablets while those in the observation group were additionally treated with baoji oral liquid.After 7 d of treatment,clinical curative effect,disappearance time of clinical symptoms,gastrointestinal hormones(gastrin,motilin,pepsinogen Ⅰ,pepsinogen Ⅱ),serum inflammatory factors(sIL-2R,IL-2,CRP)and occurrence of adverse reac-tions were compared between the two groups.Results After treatment,the total effective rate of treatment was higher in the observation group than that in the control(94.34％(50/53)vs 79.25％(42/53))(χ2=5.267,P<0.05).Compared with the con-trol group,the observation group had earlier disappearance of abdominal pain,diarrhea,vomiting,and fever symptoms af-ter treatment(P<0.05).The levels of gastrin,motilin,pepsinogen Ⅰ and pepsinogen Ⅱ were(133.59±22.57)ng·L-1,(382.23±64.49)ng·L-1,(128.38±21.42)ng·L-1,(13.74±2.49)ng·L-1 in the observation group,which showed more significant improvement as compared with the control group((171.16±26.84)ng·L-1,(326.72±51.65)ng·L-1,(104.86±19.53)ng·L-1,(17.95±3.27)ng·L-1)(t=7.799,4.891,5.907,7.457,all P<0.05).The levels of serum sIL-2R and CRP were decreased in both groups,which were lower in the ob-servation group((304.52±40.96)kU·L-1,(8.48±1.45)mg·L-1)than in the control group((335.17±41.15)kU·L-1,(12.19±3.29)mg·L-1)(t=3.843,7.512,both P<0.05).However,the level of serum IL-2 was increased and it was higher in the observation group((71.29±12.73)ng·L-1)than in the control group((53.62±9.54)ng·L-1)(t=8.086,P<0.05).There was no significant difference in the total in-cidence of adverse reactions between the two groups during medication(P>0.05).Conclusion Baoji oral liquid combined with omeprazole enteric-coated tablet can quickly relieve clinical symptoms,improve gastrointestinal function and alleviate inflammatory response in patients with acute gastroenteritis and it has significant curative effect and few adverse reactions.
Keywords：Baoji oral liquidOmeprazole enteric-coated tabletAcute gastroenteritisGastrointestinal hormone levelSoluble interleukin-2 receptorInterleukin 2C-reactive protein
Publication Date：2025-08-25
Online Publishing Date：2025-09-01(First online date of this platform, not the publication date of the document)
Pages：5( 899-903 )