Comparison in efficacy between rosuvastatin and atorvastatin respectively in combination with amlodipine in the patients with coronary heart disease and hypertension
Zhao Yanyan
Jia Jian
Fan Pei
Li Xiaoyan
Abstract：Objective To compare the clinical effect and safety between rosuvastatin and atorvastatin respectively combined with amlodipine in elderly patients with coronary heart disease and hypertension.Methods A retrospective analysis was performed on the clinical data of 312 elderly patients with coronary heart disease and hypertension in Hebei First Rongjun Youfu Hospital be-tween February 2021 and February 2024.According to different treatment methods,these patients were divided into rosuvastatin group(n=153,rosuvastatin+amlodipine)and atorvastatin group(n=159,atorvastatin+amlodipine).The effective rate of treatment,chang-es of blood pressure(diastolic blood pressure,systolic blood pressure,heart rate(HR)),onset frequency of angina,pain duration,pain degree(Seattle angina questionnaire(SAQ)),cardiac function indexes(left ventricular ejection fraction,brain natriuretic peptide,6 min walking test),vascular endothelial factors(endothelin-1,vascular endothelial growth factor,nitric oxide),inflammatory indicators(C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor α(TNF-α))and the occurrence of adverse drug reactions were compared between the two groups.Results There was no statistically significant difference in effective rate of treatment between the two groups(89.54%vs 83.02%,P>0.05).After treatment,there was no statistically significant difference in systolic blood pres-sure,diastolic blood pressure or HR between the rosuvastatin group and atorvastatin group((120.37±5.62)mm Hg(1 mm Hg≈0.133 kPa),(79.36±5.12)mm Hg,(85.46±8.51)times·min-1 vs(125.41±6.03)mm Hg,(80.63±6.27)mm Hg,(84.33±8.01)times·min-1,P>0.05).The onset frequency and duration of angina in the rosuvastatin group were(1.02±0.27)times·d-1 and(1.39±0.26)min,lower than those in the atorvastatin group((1.58±0.26)times·d-1,(2.01±0.47)min),and SAQ score was higher than that in the atorvastatin group((72.14±4.14)points vs(67.52±4.37)points,P<0.05).The left ventricular ejection fraction and 6 min walking test in the rosu-vastatin group were(52.06±5.76)%and(546.83±22.74)m,higher than those in the atorvastatin group((48.34±6.37)%,(512.39±25.84)m),while brain natriuretic peptide was lower than that in the atorvastatin group((142.33±28.49)pg·mL-1 vs(167.86±31.26)pg·mL-1,P<0.05).Endothelin-1 in the rosuvastatin group was lower than that in the atorvastatin group((53.17±6.42)ng·mL-1 vs(62.33±5.58)ng·mL-1),while vascular endothelial growth factor and nitric oxide were higher than those in the atorvastatin group((78.26±6.67)pg·mL-1,(73.18±5.74)μmol·L-1 vs(69.78±5.35)pg·mL-1,(65.67±5.45)μmol·L-1,P<0.05).The levels of CRP,IL-6,TNF-α in the rosuvastatin group were(11.62±2.31)mg·L-1,(12.24±4.97)pg·mL-1 and(34.51±5.29)pg·mL-1,lower than those in the atorvastatin group((15.77±3.04)mg·L-1,(15.73±4.16)pg·mL-1,(44.58±6.88)pg·mL-1,P<0.05).There was no significant differ-ence in incidence of adverse drug reactions between the rosuvastatin group and atorvastatin group(9.15%vs 10.06%,P>0.05).Conclusion Curative effect of rosuvastatin+amlodipine and atorvastatin+amlodipine is comparable in elderly patients with cor-onary heart disease and hypertension.Both combinations both can effectively reduce blood pressure.Rosuvastatin can better relieve angina symptoms,improve cardiac function and vascular endothelial function,and not increase treatment risk.
Keywords：ElderlyCoronary heart disease complicated with hypertensionAmlodipineRosuvastatinAtorvastatin
Publication Date：2025-08-25
Online Publishing Date：2025-09-01(First online date of this platform, not the publication date of the document)
Pages：5( 810-814 )