Clinical evaluation of raltitrexed intraperitoneal perfusion in patients undergoing radical resection of colorectal cancer
Luo Man
Zheng Xinyi
Zhu Hualing
Abstract：Objective To investigate the effect of intraperitoneal perfusion of raltitrexed on serum alpha-fetoprotein(AFP),can-cer antigen 72-4(CA72-4)levels,and adverse reactions in patients undergoing radical resection of colorectal cancer.Methods A total of 110 colorectal cancer patients undergoing radical resection in Zhongnan Hospital of Wuhan University from April 2021 to April 2024 were enrolled and divided into a study group(n=55)and a control group(n=55).All the patients in both groups received radical resection,while those in the study group additionally received intraperitoneal perfusion of raltitrexed before ab-dominal closure.Serum AFP,CA72-4,blood routine parameters(white blood cell(WBC),platelet(PLT),hemoglobin(Hb)),liver and kidney function indices(alanine aminotransferase(ALT),aspartate aminotransferase(AST),blood urea nitrogen(BUN),se-rum creatinine(Scr)),gastrointestinal adverse reactions,and postoperative complications were compared between the two groups.Results Postoperatively,the serum AFP and CA72-4 levels decreased over time in both groups(P<0.05).The serum levels of AFP and CA72-4 in the study group on the 3rd and 7th days after surgery((4.73±1.32)μg·L-1,(8.61±1.36)U·mL-1,(3.18±1.48)μg·L-1 and(6.73±1.26)U·mL-1)were lower than those in the control group((5.41±1.81)μg·L-1,(9.15±1.31)U·mL-1,(3.87±1.39)μg·L-1,(7.22±0.75)U·mL-1)(t3 days after surgery=2.251,2.121,t7 days after surgery=2.520,2.478,all P<0.05).Postoperatively,WBC and PLT levels de-creased over time in both groups(P<0.05);at postoperative day 7,the PLT level in the study group was significantly lower than in the control group(all P<0.05);other group comparisons were statistically non-significant(P>0.05).No significant differences were found in Hb levels before and after surgery(P>0.05).Similarly,ALT,AST,BUN,and Scr levels showed no significant intergroup or temporal differences(P>0.05).The incidence of gastrointestinal adverse reactions(9.10%(5/55)vs 3.64%(2/55))and postoperative complications(3.64%(2/55)vs 7.28%(4/55))did not differ significantly between the study group and the control group(χ2=0.610,0.176,both P>0.05).Conclusion Intraperitoneal perfusion of raltitrexed effectively reduces serum AFP and CA72-4 levels in col-orectal cancer patients undergoing radical resection,and it has high tolerance and safety.
Keywords：RaltitrexedRadical resection of colorectal cancerIntraperitoneal perfusion chemotherapyAlpha-fetoproteinCan-cer antigen 72-4Adverse reaction
Publication Date：2025-08-25
Online Publishing Date：2025-09-01(First online date of this platform, not the publication date of the document)
Pages：5( 801-805 )