Efficacy of alteplase combined with edaravone in the treatment of patients with mild ischemic stroke
Shi Yanjie
Shi Xueying
Tang Xiangyang
Cao Li
Li Bo
Abstract：Objective To explore the application value of rt-PA intravenous thrombolysis combined with edaravone in patients with acute ischemic stroke(AIS)of low National Institutes of Health Stroke Scale(NIHSS)score.Methods A retrospective analysis was conducted on the clinical data of 86 patients with AIS and low NIHSS score(≤5 points)admitted to Anqing Municipal Hospital from January 2023 to February 2024.The patients in the control group received conventional treatment combined with rt-PA intravenous thrombolysis,while those in the study group received rt-PA intravenous thrombolysis combined with edaravone treatment.The two groups were compared in clinical efficacy,neural injury markers(brain-derived neurotrophic factor(BDNF),neuron-specific enolase(NSE)),hemorheological indicators,bleeding complications,and the prognosis.Results The total effective rate was 93.02%in the study group and 74.42%in the control group,with a statistically significant difference(χ2=4.181,P<0.05).Post-treatment BDNF levels of the study group and the control group((4.48±0.58)μg·L-1,(3.85±0.32)μg·L-1)were higher than pre-treatment levels((3.15±0.22)μg·L-1,(3.09±0.25)μg·L-1),and these indicators were higher in the former group,with a statistically significant difference(t=6.237,P<0.05).Post-treatment NSE levels of the study group and the control group((5.26±1.02)μg·L-1,(9.36±1.22)μg·L-1)were lower than pre-treatment levels((17.86±2.15)μg·L-1,(18.05±2.26)μg·L-1),and these indicators were lower in the former group,with a statistically significant difference(t=16.907,P<0.05).Post-treatment whole blood low shear viscosity,whole blood medium shear viscosity and whole blood high shear viscosity in the study group and the control group((7.25±1.23)mPa·s,(6.38±0.78)mPa·s,(5.67±0.59)mPa·s,(9.56±1.38)mPa·s,(7.39±0.82)mPa·s,(6.71±0.62)mPa·s)were lower than pre-treatment values((11.54±1.58)mPa·s,(8.58±1.31)mPa·s,(7.28±0.85)mPa·s,(11.75±1.62)mPa·s,(8.45±1.26)mPa·s,(7.25±0.92)mPa·s),and these indices were lower in the former group,with statistically significant differences(t=8.194,5.852,7.968,all P<0.05).The complication rate was 4.65%in the study group and 9.30%in the control group,with a statistically significant difference(χ2=5.800,P<0.05).After 90 days of follow-up,mRS scores of the study group and the control group were(2.28±0.21)points and(3.01±0.45)points,and the former was lower;the proportions of patients with good prognosis were 86.05%and 65.12%,and the former was higher,with statistically significant differences(t=9.640,χ2=5.103,both P<0.05).Conclusion The combination of rt-PA intravenous thrombolysis and edaravone can achieve good therapeutic effects on AIS since it can improve the levels of neural injury and hemorheological indicators,and has good safety and prognosis.
Keywords：Acute ischemic strokeAlteplaseIntravenous thrombolysisEdaravoneHemorheology
Publication Date：2025-08-25
Online Publishing Date：2025-09-01(First online date of this platform, not the publication date of the document)
Pages：4( 770-773 )