Clinical research on effect of stronger neo-minophagen C combined with reduced glutathione on relieving antituberculosis therapy-related liver injury

Xia Ming; Wang Fei; Chen Hemin

doi:10.3969/j.issn.1672-8157.2025.03.015

Abstract：Objective To observe the effect of stronger neo-minophagen C(SNMC)combined with reduced glutathione(GSH)on relieving the antituberculosis therapy-related liver injury.Methods A total of 98 patients with antituberculosis therapy-related liver injury who were admitted to the Jiangshan People's Hospital from January 2020 to August 2024 were divided into the silybin group treated with conventional treatment and silybin,and the combination group treated with SNMC and GSH on the basis of the silybin group.The enrolled patients were randomly grouped,and both groups were treated continuously for 2 weeks.The clinical effi-cacy,serum oxidative stress indexes,inflammatory factors,liver function indexes and safety were compared between the two groups.Results The total effective rate of the combination group was 91.84%(45/49)after the treatment,higher than 75.51%(37/49)of the silybin group(χ2=4.780,P<0.05).The levels of serum superoxide dismutase and glutathione peroxidase of the combination group and the silybin group were respectively(589.52±71.37)U·L-1,(73.41±8.40)U·L-1 and(519.82±62.74)U·L-1 and(66.29±7.17)U·L-1 after the treatment,higher than(324.06±44.17)U·L-1,(52.78±7.29)U·L-1 and(321.73±39.82)U·L-1,(53.92±6.72)U·L-1 before the treatment.The levels of the above indexes of the combination group were higher than those of the silybin group(t=5.134,4.513,P<0.05).The levels of serum malondialdehyde were respectively(3.89±1.14)nmol·L-1 and(6.17±1.95)nmol·L-1 after the treatment,lower than(8.69±2.77)nmol·L-1 and(8.35±2.51)nmol·L-1 before the treatment.The levels of the above indexes of the combination group were lower than those of the silybin group(t=7.066,P<0.05).The levels of serum interleukin-6,interleukin-1β and tumor C-reactive protein of the combination group and the silybin group were respectively(3.88±1.27)ng·L-1,(10.69±2.50)μg·L-1,(8.59±2.05)mg·L-1 and(8.44±2.39)ng·L-1,(22.48±4.03)μg·L-1 and(16.27±4.52)mg·L-1 after the treatment,lower than[(19.33±4.52)ng·L-1,(58.11±8.51)μg·L-1,(23.10±6.83)mg·L-1 and(18.53±3.28)ng·L-1,(57.29±7.34)μg·L-1 and(22.47±6.02)mg·L-1 before the treatment.The levels of the above indexes of the combination group were lower than those of the silybin group(t=11.794,17.402,10.832,P<0.05).The levels of serum alanine aminotransferase,aspartate aminotransferase and γ-glutamyl transferase of the combination group and the silybin group were respectively(34.19±5.27)U·L-1,(40.95±4.72)U·L-1,(35.61±5.22)U·L-1 and(51.38±7.32)U·L-1,(57.41±7.83)U·L-1 and(57.07±8.49)U·L-1 after the treatment,lower than(150.31±25.48)U·L-1,(134.41±36.70)U·L-1,(92.41±9.40)U·L-1 and(149.78±23.69)U·L-1,(133.52±31.58)U·L-1 and(91.78±8.48)U·L-1 before the treatment.The levels of the above indexes of the combination group were lower than those of the silybin group(t=13.341,12.603,15.073,P<0.05).The total incidence of adverse reactions was 10.20%(5/49)in the silybin group,14.29%(7/49)in the combination group and there was no significant difference between the two groups(χ2=0.380,P=0.538).Conclusion SNMC combined with GSH in the treatment of patients with antituberculosis therapy-related liver injury can effectively alleviate the oxidative stress response of patients,reduce their inflamma-tory response,improve their liver function,and have good safety.