Clinical effect of Xuebijing injection combined with high-flow nasal cannula oxygen therapy on treatment of patients with severe pneumonia
Chen Hongxu
Zhang Xiaoshuang
Geng Jianwen
Gao Lin
Abstract：Objective To observe the clinical efficacy of Xuebijing injection combined with high-flow nasal cannula oxygen therapy(HFNC)in treatment of patients with severe pneumonia(SP).Methods A total of 62 patients with SP who were admitted to Leshan Traditional Chinese Medicine Hospital from October 2023 to December 2024 were recruited as the research subjects and ran-domly divided into two groups.Both groups of patients received routine treatments.The control group(31 cases)was given HFNC and the treatment group(31 cases)received Xuebijing injection on the basis of the control group.Both groups were treated contin-uously for one week.The oxygen partial pressure(PaO2),carbon dioxide partial pressure(PaCO2),oxygenation index(PaO2/FiO2),leukocyte count(WBC),procalcitonin(PCT),interleukin(IL)-6 as well as the acute physiology and chronic health score(APACHEⅡ)and the clinical efficacy were observed and compared between the two groups before and after the treatment.Results The total clinical effectiveness rate of the treatment group was 90.32%(28/31),higher than 67.74%(21/31)of the control group(χ2=4.769,P<0.05).The PaCO2,APACHEⅡ score,serum WBC,PCT and IL-6 levels were respectively(48.25±3.61)mm Hg(1 mm Hg≈0.133 kPa),(12.64±2.07)points,(7.29±1.27)×109·L-1,(1.32±0.87)ng·mL-1 and(17.53±3.28)pg·mL-1 in the treatment group after the treatment,lower than(54.70±4.23)mm Hg,(15.38±2.13)points,(11.63±1.36)×109·L-1,(3.63±1.05)ng·mL-1 and(23.69±4.15)pg·mL-1 in the control group(t=6.458,5.136,12.986,9.432,6.484,all P<0.05);the PaO2 and PaO2/FiO2 of the treatment group were respectively(76.35±5.26)mm Hg and(272.78±22.46)mm Hg,higher than(67.82±5.83)mm Hg and(251.82±20.59)mm Hg of the control group(t=6.048,3.830,both P<0.05).Conclusion Xuebijing injection combined with HFNC can improve the clinical efficacy in the treatment of SP patients,effectively enhance the lung ventilation function,and regulate the inflammatory response.
Keywords：Xuebijing injectionHigh-flow nasal cannula oxygen therapySevere pneumoniaBlood routine testInflammatory factor
Publication Date：2025-06-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 384-387 )