Efficacy of Yupingfeng granule combined with acetylcysteine in children with mycoplasma neumoniae pneumonia and its impact on T lymphocytes
Feng Hui-ling
Wang Kai-yue
Song Jian-gang
Xue Zheng-feng
Abstract：Objective To investigate the efficacy of Yupingfeng granule combined with acetylcysteine in treatment of myco-plasma pneumoniae pneumoniae(MPP)and its effect on T-lymphocyte subpopulations in children with MPP.Methods A total of 102 children with MPP admitted to Yan'an University Affiliated Hospital from January 2021 to January 2023 were selected for ret-rospective analysis and divided into the control group(n=51)and the experimental group(n=51)according to the treatment method.Children of the control group were treated with acetylcysteine and those of the experimental group were treated with acetylcysteine combined with Yupingfeng granules.Comparison of clinical efficacy,symptom improvement time,T-lymphocyte subpopulation changes and the incidence of adverse effects was performed between the two groups.Results The overall effective rate after treat-ment was 96.08%(49/51)in the experimental group and 82.35%(42/51)in the control(χ2=4.993,P=0.025).The time for cough,fever,wheezing,and rales to subside in children in the experimental group((5.35±0.89)d,(3.23±0.65)d,(2.67±0.58)d,and(5.74±0.78)d)were all shorter than that in the control group((6.12±1.32)d,(4.01±0.96)d,(3.54±0.84)d,and(6.45±1.12)d)(t=3.454,4.805,6.087,3.715,all P<0.001).The CD3+,CD4+,CD4+/CD8+levels of T-lymphocyte subpopulations((65.87±7.23)%,(36.87±7.23)%,(1.47±0.42),(61.23±6.18)%,(31.23±6.12)%,and(1.26±0.25))were higher than that before the treatment in the experimental group and the control((54.46±5.59)%,(26.45±5.59)%,(0.95±0.24),(54.14±5.37)%,(26.14±5.37)%,(0.93±0.21)),and they were higher in the experimental group than in the control(t=3.484,4.252,3.068,all P<0.05).The total incidence of adverse reactions in the two groups was 9.80%(5/51)and 5.88%(3/51),respectively,and the difference was not statistically significant(χ2=0.136,P=0.713).Conclusion The efficacy of Yupingfeng granules combined with acetylcysteine in the treatment of children with MPP is remark-able because it can alleviate the symptoms and improve the distribution of T-lymphocyte subpopulations more quickly,and has high safety profile.
Keywords：Yupingfeng granuleAcetylcysteineMycoplasma pneumoniae pneumoniaT-lymphocyte subsetClinical efficacy
Publication Date：2025-04-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 352-355 )