Efficacy and adverse reactions of compound betamethasone combined with excimer laser therapy in patients with non-segmental vitiligo
Lyv Hui-qing
Yu Xiao-qian
Qin Xu-yan
Lu Xiao-lin
Abstract：Objective To observe the clinical efficacy and adverse effects of compound betamethasone combined with 308 nm excimer laser therapy in treatment of non-segmental vitiligo.Methods A total of 64 patients with stable non-segmental vitiligo ad-mitted to Qingdao Hiser Hospital from January 2024 to April 2024 were included in this study and divided into two groups using the random number table method,with 32 in each groups.All the patients in both groups were treated with 308 nm excimer laser therapy three times a week for 12 weeks,and those in the research group were additionally treated with compound betamethasone muscle injection once every 3 weeks for 4 injections.The clinical efficacy,vitiligo area scoring index(VASI),skin lesion area improvement,skin lesion pigment score,intercellular cell adhesion molecule 1(ICAM-1),tumor necrosis factor α(TNF-α)and the occurrence of adverse reactions were compared between the two groups.Results The effective rate in the research group was 90.63%(29/32),higher than 68.75%(22/32)in the control group(χ2=4.730,P<0.05).After treatment,the VASI scores of both groups decreased,and the score of the research group((1.29±0.34)points)was lower than the control group((1.72±0.45)points)(t=4.313,P<0.05).The skin lesion areas of both groups were reduced,and it was lower in the research group((17.26±2.31)cm2)than in the control group((21.83±2.42)cm2)(t=7.727,P<0.05).The skin lesion pigment scores of both groups increased,and they were higher in the research group((2.05±0.16)points)than in the control group((1.73±0.14)points)(t=8.514,P<0.05).The levels of ICAM-1 and TNF-α in both groups were reduced,and they were lower in the research group((514.26±70.34)pg·L-1,(9.15±1.56)pg·mL-1)than in the con-trol group((552.82±72.41)pg·L-1,(10.73±2.14)pg·mL-1)(t=2.329,3.375,P<0.05).The adverse reaction rate was 9.38%(3/32)in research group,which was lower than that of 15.63%(5/32)in the control group(χ2=0.143,P>0.05).Conclusion Compound beta-methasone combined with 308 nm excimer laser therapy has a good clinical effect on non-segmental vitiligo.It can reduce the area of vitiligo skin lesions,improve the color of the skin lesions,and reduce the level of inflammation factors while ensuring safety.
Keywords：Compound betamethasoneLaser therapyNon-segmental vitiligoEfficacy
Publication Date：2025-04-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 315-318 )