Efficacy and regulatory effect on immune function of compound glycyrrhizin combined with excimer light in treatment of patients with vitiligo

Feng Shi-ke; Liu Wang; He Hong-yi; Li Li; Zhong Yan; Wang Hai-xia

doi:10.3969/j.issn.1672-8157.2025.02.020

Abstract：Objective To explore the clinical efficacy of compound glycyrrhizin tablets combined with 308 nm excimer light in the treatment of vitiligo and its regulatory effect on immune function.Methods A total of 89 patients with vitiligo admitted to Zigong First People's Hospital from May 2022 to April 2023 were selected and randomly divided into the control group(n=44)and the experimental group(n=45)by random number table method.Patients in the control group were treated with 308 nm excimer light while those in the experimental group with compound glycyrrhizin tablets combined with 308 nm excimer light.All the patients in both groups were treated for 3 months.The clinical efficacy,adverse reactions,and changes in immune indicators and lesion scores before and after treatment were compared between the two groups.Results The clinical cure rate of the experimental group was 97.78%(44/45),which was higher than that of the control(77.27%,34/44)(χ2=8.636,P<0.05).Compared with pre-treatment levels,the levels of CD3+,CD4+,and CD8+in both the experimental group and the control group patients showed an increase(pre-treat-ment levels in the experimental group were(62.93±12.10)%,(30.40±6.85)%,and(20.01±6.31)%and those in the control group were(61.17±11.39)%,(30.38±6.88)%,and(20.36±6.96)%respectively)after treatment.The levels of CD4+/CD8+in both the experimental group and the control group patients showed a decrease(pre-treatment level in the trial group was(1.56±0.98)and that in the control group was(1.60±0.25)).The levels of CD3+,CD4+,and CD8+in the experimental group were(71.36±13.32)%,(39.69±5.21)%and(26.39±6.35)%,which were significantly higher than those in the control group((65.32±10.13)%,(36.33±9.81)%and(23.89±5.36)%),and the differences were statistically significant(t=2.404,2.024,3.091,all P<0.05).The level of CD4+/CD8+in the experimental group was(1.40±0.15),which was significantly lower than that in the control((1.50±0.31)),and the difference was statistically obvi-ous(t=3.418,P<0.05).The lesion area score and lesion pigment score in both the experimental group and the control group patients((0.52±0.26)points,(0.36±0.14)points,(1.71±0.36)points and(1.88±0.46)points)were lower than those before treatment((2.34±0.21)points,(2.11±0.46)points,(2.33±0.23)points and(2.15±0.45)points).Furthermore,the lesion area score and lesion pigment score in the experimental group were lower than those in the control(t=17.907,21.188,both P<0.05).The total incidence of adverse reactions was 6.82%(3/44)in the control group and 4.44%(2/45)in the experimental group,showing no statistically significant difference be-tween the two groups(χ2=0.236,P>0.05).Conclusion The combination of compound glycyrrhizin tablets and 308 nm excimer light in the treatment of vitiligo has significant clinical efficacy.It enhances the immune function of patients by regulating peripheral blood immune cells,achieving ideal therapeutic effects.